Department of Neurobiology, A, I, Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P,O, Box 1627, 70211 Kuopio, Finland.
J Neuroinflammation. 2013 Oct 31;10:133. doi: 10.1186/1742-2094-10-133.
ADAMTS-1, -4, -5 and -9 belong to 'a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)' family and more precisely to the proteoglycanases subgroup based on their common ability to degrade chondroitin sulfate proteoglycans. They have been extensively investigated for their involvement in inflammation-induced osteoarthritis, and a growing body of evidence indicates that they may be of key importance in the physiological and pathological central nervous system (CNS). In this review, we discuss the deregulated expression of ADAMTS proteoglycanases during acute CNS injuries, such as stroke and spinal cord injury. Then, we provide new insights on ADAMTS proteoglycanases mediating synaptic plasticity, neurorepair, angiogenesis and inflammation mechanisms. Altogether, this review allows us to propose that ADAMTS proteoglycanases may be original therapeutic targets for CNS injuries.
ADAMTS-1、-4、-5 和 -9 属于 '解整合素金属蛋白酶与凝血酶响应素基元（ADAMTS）' 家族，根据其降解软骨素硫酸盐蛋白聚糖的共同能力，更确切地说属于蛋白聚糖酶亚群。它们因参与炎症诱导的骨关节炎而被广泛研究，越来越多的证据表明它们可能在生理和病理中枢神经系统（CNS）中具有重要意义。在这篇综述中，我们讨论了 ADAMTS 蛋白聚糖酶在急性中枢神经系统损伤（如中风和脊髓损伤）期间的失调表达。然后，我们提供了关于 ADAMTS 蛋白聚糖酶介导突触可塑性、神经修复、血管生成和炎症机制的新见解。总的来说，这篇综述使我们能够提出 ADAMTS 蛋白聚糖酶可能是中枢神经系统损伤的原始治疗靶点。
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