Department of Cardiology, London Chest Hospital, Bonner Road, London E2 9JX, UK.
Stem Cell Res Ther. 2012 Jan 17;3(1):2. doi: 10.1186/scrt93.
Stem cell transplantation is emerging as a potential therapy to treat heart diseases. Promising results from early animal studies led to an explosion of small, non-controlled clinical trials that created even further excitement by showing that stem cell transplantation improved left ventricular systolic function and enhanced remodelling. However, the specific mechanisms by which these cells improve heart function remain largely unknown. A large variety of cell types have been considered to possess the regenerative ability needed to repair the damaged heart. One of the most studied cell types is the bone marrow-derived mononuclear cells and these form the focus of this review. This review article aims to provide an overview of their use in the setting of acute myocardial infarction, the challenges it faces and the future of stem cell therapy in heart disease.
干细胞移植作为一种治疗心脏病的潜在疗法正在兴起。早期动物研究的有希望的结果导致了大量小型、非对照临床试验的爆发，这些试验通过显示干细胞移植改善左心室收缩功能和增强重塑，进一步引起了兴奋。然而，这些细胞改善心脏功能的具体机制在很大程度上仍然未知。已经有多种细胞类型被认为具有修复受损心脏所需的再生能力。其中研究最多的细胞类型之一是骨髓来源的单核细胞，这是本综述的重点。本文旨在概述它们在急性心肌梗死中的应用、面临的挑战以及干细胞治疗在心脏病中的未来。
