一种与黑腹果蝇3D4染色粒相关的环磷酸腺苷磷酸二酯酶的基因独特形式。
A genetically distinct form of cyclic AMP phosphodiesterase associated with chromomere 3D4 in Drosophila melanogaster.
作者信息
Kiger J A, Golanty E
出版信息
Genetics. 1979 Mar;91(3):521-35. doi: 10.1093/genetics/91.3.521.
Two cyclic AMP phosphodiesterase enzymes (E.C.3.1.4.17) are present in homogenates of adult Drosophila melanogaster. The two enzymes differ from one another in heat stability, affinity for Mg++, Ca++ activation and molecular weight. They do not differ markedly in their affinities for cyclic AMP, and both exhibit anomalous Michaelis-Menten kinetics. The more heat-labile enzyme is controlled in a dosage-dependent manner by chromomere 3D4 of the X chromosome and is absent in flies that are deficient for chromomere 3D4. Chromomere 3D4 is also necessary for the maintenance of normal cAMP levels, for male fertility, and for normal female fertility and oogenesis. The structural gene(s) for the more heat-stable enzyme is located outside of chromomeres 3C12-3D4. Whether 3D4 contains a structural gene, or a regulatory gene necessary for the presence of the labile enzyme, remains to be determined.
在成年黑腹果蝇的匀浆中存在两种环磷酸腺苷磷酸二酯酶（E.C.3.1.4.17）。这两种酶在热稳定性、对Mg++的亲和力、Ca++激活作用以及分子量方面彼此不同。它们对环磷酸腺苷的亲和力没有显著差异，并且都表现出异常的米氏动力学。热稳定性较差的那种酶受到X染色体的染色粒3D4以剂量依赖方式的调控，在缺乏染色粒3D4的果蝇中不存在。染色粒3D4对于维持正常的环磷酸腺苷水平、雄性生育力以及正常的雌性生育力和卵子发生也是必需的。热稳定性较高的那种酶的结构基因位于染色粒3C12 - 3D4之外。3D4是包含一个结构基因，还是对于不稳定酶的存在是必需的调控基因，仍有待确定。
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