果蝇中影响环磷酸腺苷磷酸二酯酶活性的染色体区域单体缺失的后果。
The consequences of nullosomy for a chromosomal region affecting cyclic AMP phosphodiesterase activity in Drosophila.
作者信息
Kiger J A
出版信息
Genetics. 1977 Apr;85(4):623-8. doi: 10.1093/genetics/85.4.623.
Abstract
A study of Drosophila nullosomic for chromomere 3D4 shows that this region of the genome is necessary for male fertility, normal female fertility and normal oogenesis. Males nullosomic for 3D4 lack normal, motile sperm. Females nullosomic for this region exert a maternal influence on their progeny which results in a diversity of imaginal defects. The observation that chromomere 3D4 is the most probable locus for a chromosomal region which affects cAMP phosphodiesterase activity, and which may contain a structural gene for the enzyme, prompts the hypothesis that the diverse physiological effects caused by nullosomy for 3D4 are the result of an aberrant cAMP metabolism.
摘要
一项对缺失染色粒3D4的果蝇缺体的研究表明，基因组的这一区域对雄性生育力、正常雌性生育力和正常卵子发生是必需的。缺失3D4的雄性缺乏正常的、可游动的精子。该区域缺失的雌性对其后代产生母体影响，导致多种成虫缺陷。染色粒3D4最有可能是影响环磷酸腺苷磷酸二酯酶活性的染色体区域的位点，并且可能包含该酶的一个结构基因，这一观察结果促使人们提出这样的假说：3D4缺体所导致的多种生理效应是环磷酸腺苷代谢异常的结果。
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