Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01505, USA.
Cell. 2012 Jan 20;148(1-2):17-8. doi: 10.1016/j.cell.2011.12.020.
Programmed necrosis has long been recognized as a crucial component of animal development; however, the signaling pathway beyond the protein kinases RIP1 and RIP3 remains largely unknown. Sun et al. and Wang et al. now identify critical factors downstream of RIP1 and RIP3 in programmed necrosis, extending our understanding of this form of cell death.
程序性细胞坏死长期以来被认为是动物发育的一个重要组成部分；然而，蛋白激酶 RIP1 和 RIP3 之外的信号通路在很大程度上仍然未知。孙等人和王等人现在确定了程序性细胞坏死中 RIP1 和 RIP3 下游的关键因素，扩展了我们对这种细胞死亡形式的理解。
