Thiemermann C, Vane J
William Harvey Research Institute, St Bartholomew's Hospital Medical College, London, U.K.
Eur J Pharmacol. 1990 Jul 17;182(3):591-5. doi: 10.1016/0014-2999(90)90062-b.
E. coli lipopolysaccharide (LPS; 15 mg kg-1 i.v.) produced a long-lasting reduction in mean arterial blood pressure (MAP) in the anaesthetized rat. Inhibition of nitric oxide endothelium-derived relaxing factor (EDRF) synthesis with NG-monomethyl-L-arginine (MeArg, 1 mg kg-1 min-1 i.v. for 30 min) produced an increase in MAP and largely attenuated the LPS-induced hypotension; both effects were significantly reversed with L-arginine (6 mg kg-1 min-1 i.v.). When compared to MeArg, phenylephrine (300 mg kg-1 h-1 i.v.) produced a similar pressor response, but much less attenuation of the hypotensive response to LPS. Thus, a stimulation of EDRF release contributes to the LPS-induced hypotension in the anaesthetized rat.
大肠杆菌脂多糖（LPS；15毫克/千克静脉注射）可使麻醉大鼠的平均动脉血压（MAP）出现持久下降。用N-甲基-L-精氨酸（MeArg，1毫克/千克·分钟静脉注射30分钟）抑制一氧化氮内皮源性舒张因子（EDRF）合成，可使MAP升高，并在很大程度上减弱LPS诱导的低血压；L-精氨酸（6毫克/千克·分钟静脉注射）可使这两种效应显著逆转。与MeArg相比，去氧肾上腺素（300毫克/千克·小时静脉注射）产生了类似的升压反应，但对LPS诱导的低血压反应的减弱作用要小得多。因此，EDRF释放的刺激作用促成了麻醉大鼠中LPS诱导的低血压。
