泼尼松龙与泼尼松龙联合阿昔洛韦治疗贝尔麻痹的疗效比较。
Comparison of the efficacy of prednisolone versus prednisolone and acyclovir in the treatment of Bell`s palsy.
作者信息
Ahangar Alijan A, Hosseini Seydreza, Saghebi Roshanak
机构信息
Department of Neurology, Yahyanejad Hospital, Babol Medical Sciences University, 471466855, Babol, Iran. Tel. +98 11122225035. Fax. +98 1112290141. E-mail:
出版信息
Neurosciences (Riyadh). 2006 Oct;11(4):256-9.
OBJECTIVE
To compare the efficacy of 2 regimens of prednisolone versus prednisolone and acyclovir in the treatment of Bell`s palsy.
METHODS
A retrospective study was performed on 496 Bell`s palsy patients attending Yahyanejad Hospital, Babol, Iran from 1995 to 2004, divided in 2 groups. The first group was treated with regimen one (oral prednisolone), and the second group was treated with regimen 2 (oral prednisolone plus oral acyclovir) for 2 weeks. All cases were followed for 6 months.
RESULTS
Two hundred and forty-eight cases (108 males, 140 females) were treated with regimen one, and 248 cases (113 males, 135 females), were treated with regimen 2. Both groups had a mean age of 20-39 years. At the end of therapy, the recovery rate with regimen 2 was 95.6% (237 patients), whereas regimen one showed a recovery rate of 91.2% (226 patients) (p=0.047).
CONCLUSION
This study showed acyclovir plus prednisolone to be more effective than prednisolone alone in the treatment of Bell`s palsy.
目的
比较泼尼松龙两种治疗方案与泼尼松龙联合阿昔洛韦治疗贝尔麻痹的疗效。
方法
对1995年至2004年在伊朗巴博勒亚哈亚内贾德医院就诊的496例贝尔麻痹患者进行回顾性研究，分为两组。第一组采用方案一（口服泼尼松龙）治疗，第二组采用方案二（口服泼尼松龙加口服阿昔洛韦）治疗2周。所有病例随访6个月。
结果
248例（男108例，女140例）采用方案一治疗，248例（男113例，女135例）采用方案二治疗。两组平均年龄均为20 - 39岁。治疗结束时，方案二的恢复率为95.6%（237例患者），而方案一的恢复率为91.2%（226例患者）（p = 0.047）。
结论
本研究表明，阿昔洛韦加泼尼松龙治疗贝尔麻痹比单独使用泼尼松龙更有效。
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