Research Centre for Cardiovascular and Respiratory Rehabilitation, Department of Rehabilitation Sciences, University of Leuven, K.U. Leuven, Leuven, Belgium.
J Cardiol. 2012 Mar;59(2):220-4. doi: 10.1016/j.jjcc.2011.12.002. Epub 2012 Jan 21.
Cross-sectional studies suggest, by use of heart rate variability (HRV), that partial re-innervation of the sinus node may occur after heart transplantation (HTx). Our aim was to test this hypothesis by examining HRV in long-term longitudinal follow-up study of HTx recipients.
14 HTx recipients (11 men) were studied 1-48 (median 13) months (baseline) and 119-172 (median 141) months after HTx (follow-up). At baseline and follow-up, electrocardiographic RR interval was continuously recorded in the supine position for 20 min. The signals were analyzed in the time domain and in the frequency domain by means of power spectral analysis. RR-interval decreased significantly from baseline to follow-up (p<0.05). This was associated with an increase of total power (p<0.001), absolute low frequency (p<0.001), and high frequency power (p<0.001), but unchanged relative low frequency and high frequency power.
The observed changes in HRV during long-term follow-up after HTx are compatible with partial re-innervation of the cardiac sinus node, as has been suggested by cross-sectional studies.
横断面研究表明，心脏移植（HTx）后窦性结可能发生部分再神经支配，可通过心率变异性（HRV）检测。我们的目的是通过对 HTx 受者进行长期纵向随访研究来检验这一假说。
研究了 14 例 HTx 受者（11 名男性），分别在 HTx 前 1-48 个月（中位数 13 个月）和 HTx 后 119-172 个月（随访）时进行检查。在基线和随访时，受者取仰卧位连续记录 20 分钟心电图 RR 间期。采用功率谱分析方法，在时域和频域对信号进行分析。RR 间期从基线到随访显著降低（p<0.05）。这与总功率（p<0.001）、绝对低频（p<0.001）和高频功率（p<0.001）增加有关，但相对低频和高频功率不变。
HTx 后长期随访期间 HRV 的观察到的变化与窦性结的部分再神经支配一致，这与横断面研究的结果一致。
