配体的齿合度控制基于 DNA 的不对称催化中的对映体选择性。
Ligand denticity controls enantiomeric preference in DNA-based asymmetric catalysis.
机构信息
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
出版信息
Chem Commun (Camb). 2012 Feb 28;48(18):2394-6. doi: 10.1039/c2cc17350f. Epub 2012 Jan 23.
PMID:22266945
Abstract
DNA-based catalysis can be used to control the enantioselectivity of copper-catalysed Diels-Alder and Friedel-Crafts reactions to produce either enantiomer of the product by changing the denticity of the ligand coordinated to the Cu(II) ion, even though the DNA adopts a right handed helical conformation only.
摘要
基于 DNA 的催化可以用来控制铜催化的 Diels-Alder 和 Friedel-Crafts 反应的对映选择性，通过改变与 Cu(II)离子配位的配体的齿密度，即使 DNA 仅采用右手螺旋构象，也可以产生产物的任一个对映异构体。
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