Dressel H
Institut für Arzneimittelwesen der DDR, Berlin.
Pharmazie. 1987 Oct;42(10):671-4.
In rabbits, the repeated i. v. injection of bacterial lipopolysaccharide very quickly induces partial pyrogen tolerance if the injections are made at intervals of 1d. Evidently, this tolerance is without effect on the temperature increases due to subsequent sodium nucleinate injections, i. e. there is no cross tolerance between the bacterial lipopolysaccharide used for comparison and sodium nucleinate. A repeated sodium nucleinate injection, if made at intervals of 1d, does not induce pyrogen tolerance either under the experimental conditions chosen. Evidently, the temperature increases due to subsequent injections of the bacterial lipopolysaccharide used for comparison are not affected by preceding sodium nucleinate injections.
在家兔中，如果每隔1天静脉注射一次细菌脂多糖，重复注射会很快诱导出部分热原耐受性。显然，这种耐受性对随后注射核酸钠引起的体温升高没有影响，即用于比较的细菌脂多糖和核酸钠之间不存在交叉耐受性。在所选的实验条件下，每隔1天重复注射核酸钠也不会诱导热原耐受性。显然，先前注射核酸钠不会影响随后注射用于比较的细菌脂多糖所引起的体温升高。
