Gendenshteĭn E I, Kostin Ia V, Markelova N N, Balashov V P, Oleĭnikov V E, Perevarin A V
Farmakol Toksikol. 1990 Jul-Aug;53(4):28-30.
The protective and therapeutic effects of some antiarrhythmic drugs of classes I-IV were studied in the experiments on 103 cats and 75 dogs. The antiarrhythmic drugs of classes 1a (N-propylaimaline bromide, aimaline, ethacizine), 1b (trimecaine) and IV (finoptine) were shown to prevent with various effectiveness the occurrence of early occlusion and reperfusion ventricular arrhythmias. The antiarrhythmic drugs of classes II (anapriline) and III (cordaron) proved to be ineffective in these cases. Ventricular arrhythmia in dogs occurring at the late stage of experimental infarction is reliably relieved in all cases with the antiarrhythmic drugs of class 1a, in most cases--those of classes 1b and III. The antiarrhythmic drugs of classes II and III are ineffective on this model. The experimental results analysed with regard to modern concepts of the genesis of modelled arrhythmias may be used as the experimental basis for a rational choice of antiarrhythmic drugs.
在对103只猫和75只狗进行的实验中，研究了I-IV类某些抗心律失常药物的保护和治疗作用。结果表明，1a类（溴化N-丙基阿马林、阿马林、乙胺碘呋酮）、1b类（三甲卡因）和IV类（非诺帕明）抗心律失常药物能以不同程度有效地预防早期闭塞和再灌注性室性心律失常的发生。II类（心得安）和III类（胺碘酮）抗心律失常药物在这些情况下被证明无效。在实验性梗死后期发生的犬室性心律失常，使用1a类抗心律失常药物在所有情况下都能得到可靠缓解，在大多数情况下，1b类和III类药物也有效。II类和III类抗心律失常药物在该模型上无效。根据现代关于模拟心律失常发生机制的概念对实验结果进行分析，可为合理选择抗心律失常药物提供实验依据。
