Khegaĭ M D
Farmakol Toksikol. 1990 Jul-Aug;53(4):42-3.
In the animal experiment the sensitivity to acetylcholine was shown to increase in alloxan-induced hypoinsulinemia. The blockade of M-cholinoreactive structure produced by administration of amizil caused a deterioration of the condition of the animals with alloxan-induced diabetes. The increased sensitivity to acetylcholine was accompanied by changes in the activity of acetylcholine esterase in the hypothalamus nuclei.
在动物实验中，已表明在四氧嘧啶诱导的低胰岛素血症中对乙酰胆碱的敏感性会增加。给予阿米齐尔产生的M-胆碱反应性结构的阻断导致四氧嘧啶诱导的糖尿病动物状况恶化。对乙酰胆碱敏感性的增加伴随着下丘脑核中乙酰胆碱酯酶活性的变化。
