Daveau M, Davrinche C, Djelassi N, Lemetayer J, Julen N, Hiron M, Arnaud P, Lebreton J P
INSERM Unité 78, BP 73, 76233 Bois-Guillaume, France.
FEBS Lett. 1990 Oct 29;273(1-2):79-81. doi: 10.1016/0014-5793(90)81055-s.
Liver mRNA levels of two acute phase reactant (APR) proteins, alpha 2-HS glycoprotein (a major negative APR) and alpha 1-acid glycoprotein (a major positive APR) were measured in male rats at different times after the administration of turpentine, of tumor necrosis factor, or following partial hepatectomy. In every case, a marked decrease in mRNA levels of alpha 2-HS glycoprotein was observed which reached a maximum at 24 h. A concomitant increase of alpha 1-acid glycoprotein mRNA levels was observed under the same conditions. These results indicate that the decreased levels of alpha 2-HS glycoprotein induced by the acute-phase response following inflammatory mediators and partial hepatectomy are due to a down-regulation of the gene expression of this protein in rat liver.
在给雄性大鼠注射松节油、肿瘤坏死因子后或部分肝切除术后的不同时间，检测了两种急性期反应（APR）蛋白，即α2-HS糖蛋白（一种主要的负急性期反应蛋白）和α1-酸性糖蛋白（一种主要的正急性期反应蛋白）在肝脏中的mRNA水平。在每种情况下，均观察到α2-HS糖蛋白的mRNA水平显著下降，在24小时时达到最大值。在相同条件下，观察到α1-酸性糖蛋白mRNA水平同时升高。这些结果表明，炎症介质和部分肝切除术后急性期反应诱导的α2-HS糖蛋白水平降低是由于该蛋白在大鼠肝脏中的基因表达下调所致。
