Department of Dermatology, Venereology and Allergology, University Hospital of Würzburg, Würzburg, Germany.
Dermatology. 2011;223(4):293-300. doi: 10.1159/000335371. Epub 2012 Jan 24.
Bowen's disease (BD) of the nail unit is associated with human papillomavirus (HPV) infection.
This study aimed to investigate the frequency of high-risk HPV infection, gender, age and digital distribution in this condition.
Biopsy specimens of 3 consecutive cases with periungual BD were investigated for the presence of HPV DNA by in situ hybridization and by polymerase chain reaction (PCR). Furthermore, 74 cases of ungual BD conducted with HPV genotyping as reported in the literature were reviewed.
PCR of biopsy specimens revealed in 2 cases infection with HPV-16 and in 1 case with HPV-73. Additionally, in 1 HPV-16-positive case HPV-31/33 was detected by in situ hybridization. In line, review of the literature demonstrated a clear association of HPV-positive BD with high-risk HPV types. Interestingly, age at diagnosis was significantly lower in women. Whereas in both genders the second to fourth fingers on both hands were commonly diseased, only in men the thumbs were also prominently affected.
Infection with high-risk HPV types is common in BD of the nail unit suggesting the aetiological cause. Therefore, patients and partners should be closely followed up for digital and genital HPV-associated lesions.
甲单位 Bowen 病（BD）与人类乳头瘤病毒（HPV）感染有关。
本研究旨在调查该疾病中高危 HPV 感染、性别、年龄和手指分布的频率。
通过原位杂交和聚合酶链反应（PCR），对 3 例连续的甲周 BD 活检标本进行 HPV DNA 检测。此外，还对文献中报道的 74 例甲 BD 进行了 HPV 基因分型。
PCR 检测到 2 例标本感染 HPV-16，1 例感染 HPV-73。此外，1 例 HPV-16 阳性病例通过原位杂交检测到 HPV-31/33。与文献综述一致的是，HPV 阳性 BD 与高危 HPV 类型明显相关。有趣的是，女性的诊断年龄明显更低。虽然在两性中，双手的第二至第四手指都常受累，但只有男性的拇指也明显受累。
高危 HPV 型感染在甲单位 Bowen 病中很常见，提示病因。因此，应密切随访患者及其伴侣的手部和生殖器与 HPV 相关的病变。
