Borioni R, Weltert L, De Paulis R, Bellisario A, Maselli D, Tomai F, Garofalo M
Department of Cardiovascular Sciences, European Hospital, Rome, Italy.
J Cardiovasc Surg (Torino). 2012 Jun;53(3):363-7. Epub 2012 Jan 24.
This study reports results of synchronous carotid endarterectomy (CEA) and off-pump coronary artery bypass grafting (CABG) in further support of the hypothesis that carotid and coronary artery revascularization can be safely performed in most patients.
The series includes 74 consecutive patients underwent synchronous CEA and off-pump CABG (group A) compared with 50 patients undergoing synchronous CEA and on-pump CABG (group B). Primary endpoint of this study are death, stroke, perioperative myocardial infarction and need for repeated revascularization within 30 days of the procedures. The secondary endpoint includes local and systemic complications.
No stroke was observed in group A. Ipsilateral minor stroke occurred in two patients of group B (4%). Two deaths within 30 days were observed in group A (2.7%) compared with 4 deaths in group B (8%). Combined stroke/death rate at 30 days was 2.7% in group A compared with 12% in group B (P< 0.05). No significant differences in myocardial infarction, local and systemic complications were observed.
Synchronous CEA and off-pump CABG may reduce the high surgical risk of patients who actually require combined carotid and coronary revascularization. This opinion has to be substantiated by larger studies and randomized trial.
本研究报告同期颈动脉内膜切除术(CEA)与非体外循环冠状动脉旁路移植术(CABG)的结果,以进一步支持以下假设:在大多数患者中可以安全地进行颈动脉和冠状动脉血运重建。
该系列研究纳入了74例连续接受同期CEA与非体外循环CABG的患者(A组),并与50例接受同期CEA与体外循环CABG的患者(B组)进行比较。本研究的主要终点是手术30天内的死亡、卒中、围手术期心肌梗死以及再次血运重建的需求。次要终点包括局部和全身并发症。
A组未观察到卒中。B组有2例患者发生同侧轻度卒中(4%)。A组在30天内观察到2例死亡(2.7%),而B组有4例死亡(8%)。A组30天的卒中/死亡率为2.7%,而B组为12%(P<0.05)。在心肌梗死、局部和全身并发症方面未观察到显著差异。
同期CEA与非体外循环CABG可能降低实际需要联合颈动脉和冠状动脉血运重建患者的高手术风险。这一观点必须通过更大规模的研究和随机试验来证实。