Chappell Jeaneen A, Chu Melinda B, Martin Katherine, Hurley M Yadira
Saint Louis University School of Medicine, St. Louis, MO, USA.
J Drugs Dermatol. 2012 Feb;11(2):247-9.
Acitretin, a metabolite of the aromatic retinoid etretinate, has been utilized successfully in the treatment of psoriasis since the late 1980s. Of the oral retinoids available, etretinate and acitretin are the most likely agents to induce various dose-dependent hair changes, but to our knowledge this is the first reported case of acitretin-induced poliosis. Additional cutaneous findings included skin atrophy and stickiness. Here we report a case of full body acitretin-induced poliosis with concurrent alopecia in a patient with psoriasis. A proposed mechanism for the poliosis is also presented here. Closer examination of retinoid-induced hair changes is needed in order to help physicians better counsel their patients regarding the adverse effects of acitretin and to expand the current knowledge on hair follicle biology.
阿维A是芳香维甲酸依曲替酯的代谢产物，自20世纪80年代末以来已成功用于治疗银屑病。在现有的口服维甲酸中，依曲替酯和阿维A是最有可能引起各种剂量依赖性毛发变化的药物，但据我们所知，这是首例关于阿维A引起白发症的报道。其他皮肤表现包括皮肤萎缩和黏腻感。在此，我们报告1例银屑病患者全身阿维A引起白发症并伴有同时性脱发的病例。本文还提出了白发症的一种可能机制。需要更仔细地研究维甲酸引起的毛发变化，以帮助医生更好地就阿维A的不良反应向患者提供咨询，并拓展目前关于毛囊生物学的知识。
