Herink C, Schön M P, Mößner R
Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Göttingen, Georg-August-Universität, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland,
Hautarzt. 2015 Aug;66(8):617-9. doi: 10.1007/s00105-015-3579-z.
The retinoid alitretinoin is a therapeutic option for chronic refractory hand eczema. Dryness of skin and mucosa, erythema, pruritus and alopecia are typical cutaneous side effects.
We report the case of a 44-year-old man whose head hair became curly while taking alitretinoin. Other causes could not be elicited as the patient was otherwise healthy, did not take any other drugs, and denied any specific physical or mental stress.
Until now there has been no report about hair curling under alitretinoin. Case reports exist for the retinoids acitretin, isotretinoin and etretinate and for other drugs such as valproat or EGFR tyrosine-kinase inhibitors. The underlying pathogenetic mechanisms are still unclear. With regard to retinoids, an influence on the keratinisation of the inner root sheath has been speculated; however further investigation will be needed to better understand the processes.
维甲酸类药物阿利维A酸是治疗慢性难治性手部湿疹的一种选择。皮肤和黏膜干燥、红斑、瘙痒和脱发是典型的皮肤副作用。
我们报告一例44岁男性患者，其在服用阿利维A酸期间头发变卷曲。由于患者其他方面健康，未服用任何其他药物，且否认有任何特殊的身体或精神压力，因此未发现其他病因。
迄今为止，尚无关于服用阿利维A酸后头发卷曲的报道。有关于维甲酸类药物阿维A、异维A酸和依曲替酯以及其他药物（如丙戊酸或表皮生长因子受体酪氨酸激酶抑制剂）导致头发卷曲的病例报告。其潜在的发病机制仍不清楚。关于维甲酸类药物，有人推测其对内根鞘角质化有影响；然而，需要进一步研究以更好地了解这些过程。
