Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Nat Med. 2012 Jan 22;18(2):224-6. doi: 10.1038/nm.2608.
Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E(2) (PGE(2)) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE(2) in the promotion of tumor progression.
虽然异常的 DNA 甲基化被认为是肿瘤抑制基因和 DNA 修复基因在肿瘤发生和发展过程中失活的关键途径之一，但癌症中 DNA 甲基化改变的机制仍不清楚。在这里，我们表明前列腺素 E2（PGE2）通过 DNA 甲基化沉默某些肿瘤抑制基因和 DNA 修复基因，从而促进肿瘤生长。这些发现揭示了 PGE2 在促进肿瘤进展中的一个以前未被认识到的作用。
