Pain Management Center of Paducah, Paducah, KY, USA.
Pain Physician. 2012 Jan-Feb;15(1):E1-E26.
Guideline development seems to have lost some of its grounding as a medical science. At their best, guidelines should be a constructive response to assist practicing physicians in applying the exponentially expanding body of medical knowledge. In fact, guideline development seems to be evolving into a cottage industry with multiple, frequently discordant guidance on the same subject. Evidence Based Medicine does not always provide for conclusive opinions. With competing interests of payers, practitioners, health policy makers, and third parties benefiting from development of the guidelines as cost saving measures, guideline preparation has been described as based on pre-possession, vagary, rationalization, or congeniality of conclusion. Beyond legitimate differences in opinions regarding the evidence that could yield different guidelines there are potentials for conflicts of interest and various other issues play a major role in guideline development. As is always the case, conflicts of interest in guideline preparation must be evaluated and considered. Following the development of American Pain Society (APS) guidelines there has been an uproar in interventional pain management communities on various issues related to not only the evidence synthesis, but conflicts of interest. A recent manuscript published by Chou et al, in addition to previous publications, appears to have limited clinician involvement in the development of APS guidelines, and demonstrates some of these challenges clearly. This manuscript illustrates the deficiencies of Chou et al's criticisms, and demonstrates their significant conflicts of interest, and use a lack of appropriate evaluations in interventional pain management as a straw man to support their argument. Further, this review will attempt to demonstrate that excessive focus on this straw man has inhibited critique of what we believe to be flaws in the approach.
指南制定似乎已经失去了一些医学科学的基础。在最佳情况下,指南应该是一种建设性的回应,以帮助执业医师应用不断扩展的医学知识体系。事实上,指南制定似乎正在演变成一个多元化的产业,针对同一主题存在着多种、经常相互矛盾的指导意见。循证医学并不总是能提供确凿的意见。由于支付者、医生、卫生政策制定者和第三方的利益相互竞争,他们从指南的制定中受益,将其作为节省成本的措施,因此指南的编写被描述为基于先入为主、变幻莫测、合理化或结论的亲和力。除了对可能产生不同指南的证据存在合理的意见分歧外,还存在利益冲突和各种其他问题在指南制定中发挥着重要作用。与往常一样,必须评估和考虑指南制定中的利益冲突。美国疼痛学会 (APS) 指南发布后,介入性疼痛管理界就出现了各种问题的强烈反对,不仅涉及证据综合,还涉及利益冲突。Chou 等人最近发表的一篇论文以及之前的出版物似乎表明,APS 指南的制定过程中临床医生的参与度有限,并清楚地展示了其中的一些挑战。这篇论文说明了 Chou 等人批评的不足之处,并表明他们存在重大的利益冲突,以及在介入性疼痛管理中缺乏适当的评估,以此作为支持他们论点的稻草人。此外,本文试图证明,过度关注这个稻草人,阻碍了对我们认为该方法存在缺陷的批评。