HIV 患者心理旋转时前额叶-纹状体-顶叶网络反应改变。
Altered prefronto-striato-parietal network response to mental rotation in HIV.
机构信息
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
出版信息
J Neurovirol. 2012 Feb;18(1):74-9. doi: 10.1007/s13365-011-0072-z. Epub 2012 Jan 21.
Abstract
The present study used functional magnetic resonance imaging to examine the neural substrates of mental rotation in 11 individuals with HIV infection and 13 demographically similar HIV seronegative volunteers. Individuals with HIV showed increased brain response to mental rotation in prefrontal and posterior parietal cortices, striatum, and thalamus, with significant HIV by angle interactions emerging in the prefrontal cortex and caudate. Results indicate that HIV infection is associated with altered brain response to mental rotation in fronto-striato-parietal pathways, which may reflect compensatory strategies, recruitment of additional brain regions, and/or increased neuroenergetic demands during mental rotation needed to offset underlying HIV-associated neural injury.
摘要
本研究使用功能磁共振成像技术，对 11 名 HIV 感染者和 13 名在人口统计学上相似的 HIV 阴性志愿者的心理旋转的神经基质进行了研究。HIV 感染者的前额叶和顶叶后皮质、纹状体和丘脑对心理旋转的大脑反应增加，在前额叶皮质和尾状核出现显著的 HIV 与角度的相互作用。结果表明，HIV 感染与额纹状体顶叶通路对心理旋转的大脑反应改变有关，这可能反映了补偿策略、额外脑区的招募，以及/或在心理旋转过程中需要增加神经能量需求，以抵消潜在的 HIV 相关神经损伤。
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