Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Lund University, Skåne University Hospital, 205 02 Malmö, Sweden.
Calcif Tissue Int. 2012 Mar;90(3):174-85. doi: 10.1007/s00223-011-9566-1. Epub 2012 Jan 22.
Dual-energy X-ray absorptiometry hip scans of 1,760 population-based Caucasians, 599 girls and 642 boys aged 6-19 years and 270 women and 249 men aged 20-90 years, were analyzed with the hip structural analysis (HSA) software to present age- and sex-specific normative HSA data of the femoral neck (FN). Measured traits included bone mineral density (BMD), cross-sectional area (CSA), section modulus (Z), periosteal diameter (PD), endosteal diameter (ED), cortical thickness (CT), and cross-sectional moment of inertia (CSMI). When plotting the measured traits versus age, the curves increased with higher ages until statistically significant break points were reached, for all traits at age 17 in girls and age 19 in boys. After the break points, PD and ED increased with higher ages but, as ED increased more than PD, BMD and CT decreased significantly with higher ages. The decline in BMD was counteracted by the increase in bone size so that there was only a nonstatistically significant decrease in bone strength, estimated as Z and CSMI, from break point to age 90. The partial preservation of bone strength was more obvious in men than in women as the decline in BMD was higher in women than in men, while the expansion in PD was larger in men than in women. The sex difference in the normative FN bone strength data seems to be related to sex discrepancies in the development of both bone mass and geometrical parameters during both growth and adulthood.
对 1760 名基于人群的白种人（599 名女孩和 642 名男孩，年龄为 6-19 岁；270 名女性和 249 名男性，年龄为 20-90 岁）进行了双能 X 射线吸收法髋关节扫描，使用髋关节结构分析（HSA）软件分析了年龄和性别特异性的股骨颈（FN）正常 HSA 数据。测量的特征包括骨矿物质密度（BMD）、横截面积（CSA）、截面模量（Z）、骨膜直径（PD）、骨内膜直径（ED）、皮质厚度（CT）和截面惯性矩（CSMI）。当将测量的特征与年龄作图时，曲线随年龄增加而增加，直到达到统计学上显著的转折点，在女孩 17 岁和男孩 19 岁时，所有特征都达到了转折点。在转折点之后，PD 和 ED 随年龄增加而增加，但由于 ED 增加超过 PD，BMD 和 CT 随年龄增加而显著下降。BMD 的下降被骨量的增加所抵消，因此从转折点到 90 岁，骨强度（Z 和 CSMI）仅呈非统计学显著下降。与女性相比，男性的骨强度保持得更好，因为女性的 BMD 下降幅度高于男性，而男性的 PD 扩张幅度大于女性。FN 骨强度数据的性别差异似乎与骨骼质量和几何参数在生长和成年期的发育过程中存在的性别差异有关。
