Department of Neurobiology, The Weizmann Institute, Rehovot, Israel.
Hippocampus. 2012 Jul;22(7):1635-44. doi: 10.1002/hipo.22000. Epub 2012 Jan 23.
The effects of low concentrations of caffeine and ryanodine on field excitatory postsynaptic potentials (EPSPs) and long-term potentiation (LTP) were studied in CA1 region of slices of dorsal and ventral hippocampus (DH and VH, respectively). There was a striking difference between the two regions in the magnitude of effect of both drugs, as well as the ability to interact with a tetanic stimulation to produce LTP. Low concentration of caffeine (1 mM) produced a postsynaptic increase in the slope of population EPSPs in VH, and facilitated LTP in this region. Low concentration of ryanodine (0.2 μM) was able to convert short-term potentiation (STP) to LTP in VH only. These effects are postsynaptic and they reflect a higher concentration of ryanodine receptors (RyRs) in the VH compared to the DH.
在背侧和腹侧海马体（DH 和 VH）切片的 CA1 区研究了低浓度咖啡因和 Ryanodine 对场兴奋性突触后电位（EPSP）和长时程增强（LTP）的影响。这两种药物的作用大小以及与强直刺激相互作用产生 LTP 的能力在两个区域之间存在显著差异。低浓度咖啡因（1mM）在 VH 中产生了群体 EPSP 斜率的突触后增加，并促进了该区域的 LTP。低浓度 Ryanodine（0.2μM）仅能将短期增强（STP）转换为 VH 中的 LTP。这些作用是突触后的，反映了与 DH 相比，VH 中 Ryanodine 受体（RyRs）的浓度更高。
