Radić M, Martinović Kaliterna D, Radić J
Department of Rheumatology and Clinical Immunology, University Hospital Split, Split, Croatia.
Neth J Med. 2012 Jan;70(1):12-7.
Drug-induced vasculitis is an inflammation of blood vessels caused by the use of various pharmaceutical agents. Vasculitis causes changes in the walls of blood vessels, including thickening, weakening, narrowing and scarring. Inflammation can be short-term (acute) or long-term (chronic) and can be so severe that the tissues and organs supplied by the affected vessels do not get enough blood. The shortage of blood can result in organ and tissue damage, even death. Drug-induced vasculitis is the most common form of vasculitis. The differential diagnosis between drug-induced and idiopathic vasculitic conditions may be difficult in the individual patient. Withdrawal may be helpful to distinguish between these syndromes. Withdrawal of the offending agent alone is often sufficient to induce prompt resolution of clinical manifestations, obviating the need for immunosuppressive and anti-inflammatory drugs. Increasing understanding of the pathophysiological characteristics of all inflammatory vasculitides should lead to better diagnostic and therapeutic approaches to drug-induced vasculitis.
药物性血管炎是由使用各种药物制剂引起的血管炎症。血管炎会导致血管壁发生变化，包括增厚、变薄、狭窄和瘢痕形成。炎症可以是短期的（急性）或长期的（慢性），严重时会导致受影响血管所供应的组织和器官供血不足。血液供应不足会导致器官和组织损伤，甚至死亡。药物性血管炎是血管炎最常见的形式。在个体患者中，药物性血管炎与特发性血管炎疾病之间的鉴别诊断可能很困难。停药可能有助于区分这些综合征。仅停用致病药物通常就足以促使临床表现迅速缓解，从而无需使用免疫抑制和抗炎药物。对所有炎症性血管炎病理生理特征的进一步了解应能带来更好的药物性血管炎诊断和治疗方法。
