Matarneh Ahmad, Sardar Sundus, Akkari Abdelrauof, Salameh Omar, Trivedi Naman, Abdulbasit Muhammad, Verma Navin, Miller Ronald, Ghahramani Nasrollah
Department of Nephrology, Penn State Health Milton S Hershey Medical Center, Hershey, USA.
Department of Internal Medicine, Penn State Milton S Hershey Medical Center, Hershey, USA.
J Med Case Rep. 2025 Aug 4;19(1):385. doi: 10.1186/s13256-025-05470-1.
Infective endocarditis occasionally presents with antineutrophil cytoplasmic antibody positivity, leading to diagnostic challenges and confusion, as it can be mislabeled antineutrophil-cytoplasmic-antibody-associated vasculitis. Distinguishing between these two factors is crucial for appropriate management.
In this case report, we describe a 77-year-old White non-Hispanic male patient who initially presented with features suggestive of antineutrophil-cytoplasmic-antibody-associated vasculitis but was ultimately diagnosed with infective endocarditis.
Our findings emphasize the need to rule out infective endocarditis in patients with suspected antineutrophil-cytoplasmic-antibody-associated vasculitis, as it can be the same, and management relies on different lines of therapy. Immunosuppression therapy can lead to devastating effects in patients with infective endocarditis.
感染性心内膜炎偶尔会出现抗中性粒细胞胞浆抗体阳性，这会导致诊断上的挑战和混淆，因为它可能被误诊为抗中性粒细胞胞浆抗体相关性血管炎。区分这两个因素对于恰当的治疗至关重要。
在本病例报告中，我们描述了一名77岁的非西班牙裔白人男性患者，他最初表现出提示抗中性粒细胞胞浆抗体相关性血管炎的特征，但最终被诊断为感染性心内膜炎。
我们的研究结果强调，对于疑似抗中性粒细胞胞浆抗体相关性血管炎的患者，有必要排除感染性心内膜炎，因为两者可能表现相同，而治疗则依赖于不同的治疗方案。免疫抑制疗法可能会对感染性心内膜炎患者产生毁灭性影响。
