感染性心内膜炎酷似抗中性粒细胞胞浆抗体相关性血管炎伴肾小球肾炎：一例报告
Infective endocarditis mimicking antineutrophil-cytoplasmic-antibody-associated vasculitis with glomerulonephritis: a case report.
作者信息
Matarneh Ahmad, Sardar Sundus, Akkari Abdelrauof, Salameh Omar, Trivedi Naman, Abdulbasit Muhammad, Verma Navin, Miller Ronald, Ghahramani Nasrollah
机构信息
Department of Nephrology, Penn State Health Milton S Hershey Medical Center, Hershey, USA.
Department of Internal Medicine, Penn State Milton S Hershey Medical Center, Hershey, USA.
出版信息
J Med Case Rep. 2025 Aug 4;19(1):385. doi: 10.1186/s13256-025-05470-1.
BACKGROUND
Infective endocarditis occasionally presents with antineutrophil cytoplasmic antibody positivity, leading to diagnostic challenges and confusion, as it can be mislabeled antineutrophil-cytoplasmic-antibody-associated vasculitis. Distinguishing between these two factors is crucial for appropriate management.
CASE PRESENTATION
In this case report, we describe a 77-year-old White non-Hispanic male patient who initially presented with features suggestive of antineutrophil-cytoplasmic-antibody-associated vasculitis but was ultimately diagnosed with infective endocarditis.
CONCLUSION
Our findings emphasize the need to rule out infective endocarditis in patients with suspected antineutrophil-cytoplasmic-antibody-associated vasculitis, as it can be the same, and management relies on different lines of therapy. Immunosuppression therapy can lead to devastating effects in patients with infective endocarditis.
背景
感染性心内膜炎偶尔会出现抗中性粒细胞胞浆抗体阳性，这会导致诊断上的挑战和混淆，因为它可能被误诊为抗中性粒细胞胞浆抗体相关性血管炎。区分这两个因素对于恰当的治疗至关重要。
病例报告
在本病例报告中，我们描述了一名77岁的非西班牙裔白人男性患者，他最初表现出提示抗中性粒细胞胞浆抗体相关性血管炎的特征，但最终被诊断为感染性心内膜炎。
结论
我们的研究结果强调，对于疑似抗中性粒细胞胞浆抗体相关性血管炎的患者，有必要排除感染性心内膜炎，因为两者可能表现相同，而治疗则依赖于不同的治疗方案。免疫抑制疗法可能会对感染性心内膜炎患者产生毁灭性影响。
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