新型双吲哚类抗菌化合物在减少导管定植方面的体外效力和体内功效。
In vitro potency and in vivo efficacy of a novel bis-indole antimicrobial compound in reducing catheter colonization.
机构信息
Baylor College of Medicine, Houston, Texas, USA.
出版信息
Antimicrob Agents Chemother. 2012 Apr;56(4):2201-4. doi: 10.1128/AAC.05521-11. Epub 2012 Jan 23.
Abstract
Vascular catheters coated with a novel antimicrobial agent (MBX1631) were studied for their ability to protect against bacterial colonization in vitro and in a rabbit model. MBX1631-coated catheters were significantly less likely to become colonized than control catheters both in vitro and in vivo (P < 0.001). Furthermore, device-associated infection was significantly lower in MBX1631-coated catheters than in uncoated ones (P < 0.005).
摘要
研究了一种新型抗菌剂（MBX1631）涂层的血管导管，以评估其在体外和兔模型中预防细菌定植的能力。MBX1631 涂层导管在体外和体内均比对照导管定植的可能性显著降低（P < 0.001）。此外，MBX1631 涂层导管相关感染的发生率明显低于未涂层导管（P < 0.005）。
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