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Use of antibiotic - impregnated DuraGen® to reduce the risk of infection in dura repair: an in vitro study.使用含抗生素的DuraGen®降低硬脑膜修复感染风险：一项体外研究。
Cent Eur Neurosurg. 2011 May;72(2):75-7. doi: 10.1055/s-0030-1267246. Epub 2011 Feb 22.
2
Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.新型双吲哚类抗菌药物对革兰氏阳性和革兰氏阴性临床分离株的体外活性比较。
Antimicrob Agents Chemother. 2010 Sep;54(9):3974-7. doi: 10.1128/AAC.00484-10. Epub 2010 Jul 12.
3
Effects of antibiotic-impregnated external ventricular drains on bacterial culture results: an in vitro analysis.抗生素体外引流管对细菌培养结果的影响：体外分析。
J Neurosurg. 2010 Jul;113(1):86-92. doi: 10.3171/2009.10.JNS09565.
4
Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.对耐药菌株具有强效抗菌活性的新型广谱双（咪唑啉吲哚）衍生物。
Antimicrob Agents Chemother. 2009 Oct;53(10):4283-91. doi: 10.1128/AAC.01709-08. Epub 2009 Jul 27.
5
Comparative assessment of antimicrobial activities of antibiotic-treated penile prostheses.抗生素处理后的阴茎假体的抗菌活性比较评估。
Eur Urol. 2009 Dec;56(6):1039-45. doi: 10.1016/j.eururo.2008.12.020. Epub 2008 Dec 30.
6
Intravascular catheter-related infections: advances in diagnosis, prevention, and management.血管内导管相关感染：诊断、预防及管理的进展
Lancet Infect Dis. 2007 Oct;7(10):645-57. doi: 10.1016/S1473-3099(07)70235-9.
7
Device-associated nosocomial infections in 55 intensive care units of 8 developing countries.8个发展中国家55个重症监护病房中的器械相关医院感染
Ann Intern Med. 2006 Oct 17;145(8):582-91. doi: 10.7326/0003-4819-145-8-200610170-00007.
8
Meta-analysis: methods for diagnosing intravascular device-related bloodstream infection.荟萃分析：血管内装置相关血流感染的诊断方法
Ann Intern Med. 2005 Mar 15;142(6):451-66. doi: 10.7326/0003-4819-142-6-200503150-00011.
9
Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention.血管内导管相关感染预防指南。疾病控制与预防中心。
MMWR Recomm Rep. 2002 Aug 9;51(RR-10):1-29.
10
The Role of Intravascular Devices in Sepsis.
Curr Infect Dis Rep. 2001 Dec;3(6):496-506. doi: 10.1007/s11908-001-0086-4.

新型双吲哚类抗菌化合物在减少导管定植方面的体外效力和体内功效。

In vitro potency and in vivo efficacy of a novel bis-indole antimicrobial compound in reducing catheter colonization.

机构信息

Baylor College of Medicine, Houston, Texas, USA.

出版信息

Antimicrob Agents Chemother. 2012 Apr;56(4):2201-4. doi: 10.1128/AAC.05521-11. Epub 2012 Jan 23.

DOI:10.1128/AAC.05521-11
PMID:22271864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3318368/
Abstract

Vascular catheters coated with a novel antimicrobial agent (MBX1631) were studied for their ability to protect against bacterial colonization in vitro and in a rabbit model. MBX1631-coated catheters were significantly less likely to become colonized than control catheters both in vitro and in vivo (P < 0.001). Furthermore, device-associated infection was significantly lower in MBX1631-coated catheters than in uncoated ones (P < 0.005).

摘要

研究了一种新型抗菌剂（MBX1631）涂层的血管导管，以评估其在体外和兔模型中预防细菌定植的能力。MBX1631 涂层导管在体外和体内均比对照导管定植的可能性显著降低（P < 0.001）。此外，MBX1631 涂层导管相关感染的发生率明显低于未涂层导管（P < 0.005）。