School of Chemical, Materials and Biomedical Engineering , The University of Georgia , Athens , Georgia 30602 , United States.
Department of Chemistry , The University of Georgia , Athens , Georgia 30602 , United States.
ACS Appl Mater Interfaces. 2020 Feb 26;12(8):9070-9079. doi: 10.1021/acsami.9b22442. Epub 2020 Feb 17.
The development of nonfouling and antimicrobial materials has shown great promise for reducing thrombosis and infection associated with medical devices with aims of improving device safety and decreasing the frequency of antibiotic administration. Here, the design of an antimicrobial, anti-inflammatory, and antithrombotic vascular catheter is assessed in vivo over 7 d in a rabbit model. Antimicrobial and antithrombotic activity is achieved through the integration of a nitric oxide donor, while the nonfouling surface is achieved using a covalently bound phosphorylcholine-based polyzwitterionic copolymer topcoat. The effect of sterilization on the nonfouling nature and nitric oxide release is presented. The catheters reduced viability of in long-term studies (7 d in a CDC bioreactor) and inflammation in the 7 d rabbit model. Overall, this approach provides a robust method for decreasing thrombosis, inflammation, and infections associated with vascular catheters.
具有抗污和抗菌性能的材料的发展在降低与医疗器械相关的血栓和感染方面显示出巨大的潜力，其目的是提高器械安全性和减少抗生素使用频率。在这里，通过在兔模型中进行 7 天的体内评估，研究了一种抗菌、抗炎和抗血栓血管导管。通过整合一氧化氮供体来实现抗菌和抗血栓活性，而通过共价结合的基于磷酸胆碱的聚两性离子共聚体顶涂层来实现抗污表面。本文介绍了灭菌对涂层的抗污性质和一氧化氮释放的影响。在长期研究（CDC 生物反应器中 7 天）中，导管降低了 的活力，在 7 天的兔模型中也降低了炎症反应。总的来说，这种方法为降低与血管导管相关的血栓、炎症和感染提供了一种强有力的方法。
