• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1.MicroRNA126 通过降低血管细胞黏附分子 1 的表达促进粒细胞集落刺激因子诱导的造血祖细胞动员。
Haematologica. 2012 Jun;97(6):818-26. doi: 10.3324/haematol.2011.056945. Epub 2012 Jan 22.
2
Mobilization of hematopoietic primitive and committed progenitor cells into blood in mice by anti-vascular adhesion molecule-1 antibody alone or in combination with granulocyte colony-stimulating factor.单独使用抗血管粘附分子-1抗体或与粒细胞集落刺激因子联合使用，可使小鼠造血原始祖细胞和定向祖细胞动员至血液中。
Exp Hematol. 2000 Mar;28(3):311-7. doi: 10.1016/s0301-472x(99)00151-4.
3
Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells.粒细胞集落刺激因子可诱导骨髓中蛋白酶的释放，这些蛋白酶能从造血祖细胞表面裂解c-KIT受体（CD117）。
Exp Hematol. 2003 Feb;31(2):109-17. doi: 10.1016/s0301-472x(02)01028-7.
4
Heparan sulfate mimetics can efficiently mobilize long-term hematopoietic stem cells.硫酸乙酰肝素类似物可以有效地动员长期造血干细胞。
Haematologica. 2012 Apr;97(4):491-9. doi: 10.3324/haematol.2011.047662. Epub 2011 Dec 16.
5
Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor.在粒细胞集落刺激因子动员造血祖细胞后，血管细胞黏附分子-1（CD106）在骨髓中被中性粒细胞蛋白酶切割。
Blood. 2001 Sep 1;98(5):1289-97. doi: 10.1182/blood.v98.5.1289.
6
Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment.环磷酰胺或粒细胞集落刺激因子诱导的动员可使骨髓转变为一个高蛋白水解的环境。
Exp Hematol. 2002 May;30(5):440-9. doi: 10.1016/s0301-472x(02)00788-9.
7
Mobilization of hematopoietic stem and progenitor cell subpopulations from the marrow to the blood of mice following cyclophosphamide and/or granulocyte colony-stimulating factor.环磷酰胺和/或粒细胞集落刺激因子作用后，小鼠骨髓造血干细胞和祖细胞亚群向血液的动员。
Blood. 1993 Apr 1;81(7):1960-7.
8
Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor.粒细胞集落刺激因子动员造血祖细胞的机制
Curr Opin Hematol. 2002 May;9(3):183-9. doi: 10.1097/00062752-200205000-00002.
9
Mesenchymal stromal cells induce a permissive state in the bone marrow that enhances G-CSF-induced hematopoietic stem cell mobilization in mice.间充质基质细胞在骨髓中诱导一种允许状态，增强粒细胞集落刺激因子诱导的小鼠造血干细胞动员。
Exp Hematol. 2018 Aug;64:59-70.e2. doi: 10.1016/j.exphem.2018.05.002.
10
Spontaneous and granulocyte–colony-stimulating factor-enhanced marrow response and progenitor cell mobilization in mice after myocardial infarction.心肌梗死后小鼠自发性和粒细胞集落刺激因子增强的骨髓反应和祖细胞动员。
Cytotherapy. 2010 Nov;12(7):909-18. doi: 10.3109/14653240903580262.

引用本文的文献

1
Involvement of circulating microRNAs in the pathogenesis of atherosclerosis in young patients with obesity.循环微RNA在肥胖年轻患者动脉粥样硬化发病机制中的作用
Physiol Res. 2024 Dec 31;73(S3):S755-S769. doi: 10.33549/physiolres.935467.
2
Development of VLA4 and CXCR4 Antagonists for the Mobilization of Hematopoietic Stem and Progenitor Cells.开发 VLA4 和 CXCR4 拮抗剂以动员造血干细胞和祖细胞。
Biomolecules. 2024 Aug 14;14(8):1003. doi: 10.3390/biom14081003.
3
The role of the hematopoietic stem/progenitor cells-derived extracellular vesicles in hematopoiesis.造血干细胞/祖细胞衍生的细胞外囊泡在造血过程中的作用。
Heliyon. 2024 Jul 24;10(15):e35051. doi: 10.1016/j.heliyon.2024.e35051. eCollection 2024 Aug 15.
4
Non-Classical Intercellular Communications: Basic Mechanisms and Roles in Biology and Medicine.非经典细胞间通讯：生物学和医学中的基本机制和作用。
Int J Mol Sci. 2023 Mar 29;24(7):6455. doi: 10.3390/ijms24076455.
5
Emerging roles of extracellular vesicles in normal and malignant hematopoiesis.细胞外囊泡在正常和恶性造血中的新兴作用。
J Clin Invest. 2022 Sep 15;132(18):e160840. doi: 10.1172/JCI160840.
6
A new transgene mouse model using an extravesicular EGFP tag enables affinity isolation of cell-specific extracellular vesicles.一种新型的转基因小鼠模型，使用囊外 EGFP 标签，能够实现细胞特异性细胞外囊泡的亲和分离。
Sci Rep. 2022 Jan 11;12(1):496. doi: 10.1038/s41598-021-04512-0.
7
Secretome of Stem Cells: Roles of Extracellular Vesicles in Diseases, Stemness, Differentiation, and Reprogramming.干细胞的胞外囊泡组：细胞外囊泡在疾病、干性、分化和重编程中的作用。
Tissue Eng Regen Med. 2022 Feb;19(1):19-33. doi: 10.1007/s13770-021-00406-4. Epub 2021 Nov 24.
8
Alterations in microRNA Expression during Hematopoietic Stem Cell Mobilization.造血干细胞动员过程中微小RNA表达的变化
Biology (Basel). 2021 Jul 15;10(7):668. doi: 10.3390/biology10070668.
9
Extracellular Vesicles in Innate Immune Cell Programming.固有免疫细胞编程中的细胞外囊泡
Biomedicines. 2021 Jun 23;9(7):713. doi: 10.3390/biomedicines9070713.
10
Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses.细胞外囊泡和颗粒介导的通讯塑造先天和适应性免疫反应。
J Exp Med. 2021 Aug 2;218(8). doi: 10.1084/jem.20202579. Epub 2021 Jun 28.

本文引用的文献

1
Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice.粒细胞集落刺激因子受体在单核细胞中的表达足以介导粒细胞集落刺激因子在小鼠中造血祖细胞的动员。
J Exp Med. 2011 Feb 14;208(2):251-60. doi: 10.1084/jem.20101700. Epub 2011 Jan 31.
2
Mechanisms of G-CSF-mediated hematopoietic stem and progenitor mobilization.粒细胞集落刺激因子介导的造血干细胞和祖细胞动员的机制。
Leukemia. 2011 Feb;25(2):211-7. doi: 10.1038/leu.2010.248. Epub 2010 Nov 16.
3
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.抑制 EGFR 信号转导增强 G-CSF 诱导的造血干细胞动员。
Nat Med. 2010 Oct;16(10):1141-6. doi: 10.1038/nm.2217. Epub 2010 Sep 26.
4
CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow.CXCR2 和 CXCR4 拮抗调节小鼠骨髓中中性粒细胞的迁移。
J Clin Invest. 2010 Jul;120(7):2423-31. doi: 10.1172/JCI41649.
5
The bone marrow: a site of neutrophil clearance.骨髓：中性粒细胞清除的场所。
J Leukoc Biol. 2010 Aug;88(2):241-51. doi: 10.1189/jlb.0210112. Epub 2010 May 18.
6
Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection.凋亡小体递送 microRNA-126 诱导 CXCL12 依赖性血管保护。
Sci Signal. 2009 Dec 8;2(100):ra81. doi: 10.1126/scisignal.2000610.
7
Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor.Grk6 和β-arrestin 2 募集受损导致 WHIM 综合征相关 CXCR4 突变受体内化和脱敏延迟。
PLoS One. 2009 Dec 1;4(12):e8102. doi: 10.1371/journal.pone.0008102.
8
BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells.BIO5192，一种VLA-4小分子抑制剂，可动员造血干细胞和祖细胞。
Blood. 2009 Aug 13;114(7):1340-3. doi: 10.1182/blood-2008-10-184721. Epub 2009 Jul 1.
9
Exosomes--vesicular carriers for intercellular communication.外泌体——细胞间通讯的囊泡载体。
Curr Opin Cell Biol. 2009 Aug;21(4):575-81. doi: 10.1016/j.ceb.2009.03.007. Epub 2009 May 11.
10
Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma.普乐沙福与粒细胞集落刺激因子对比安慰剂与粒细胞集落刺激因子用于动员多发性骨髓瘤患者造血干细胞以进行自体干细胞移植
Blood. 2009 Jun 4;113(23):5720-6. doi: 10.1182/blood-2008-08-174946. Epub 2009 Apr 10.

MicroRNA126 通过降低血管细胞黏附分子 1 的表达促进粒细胞集落刺激因子诱导的造血祖细胞动员。

MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1.

机构信息

Laboratory of Cellular Oncology, CCR, NCI, NIH, Bethesda, MD 20892, USA.

出版信息

Haematologica. 2012 Jun;97(6):818-26. doi: 10.3324/haematol.2011.056945. Epub 2012 Jan 22.

DOI:10.3324/haematol.2011.056945
PMID:22271895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3366645/
Abstract

BACKGROUND

Mobilization of hematopoietic stem/progenitor cells from the bone marrow to the peripheral blood by granulocyte colony-stimulating factor is the primary means to acquire stem cell grafts for hematopoietic cell transplantation. Since hematopoietic stem/progenitor cells represent a minority of all blood cells mobilized by granulocyte colony-stimulating factor, the underlying mechanisms need to be understood in order to develop selective drugs.

DESIGN AND METHODS

We analyzed phenotypic, biochemical and genetic changes in bone marrow cell populations from granulocyte colony-stimulating factor-mobilized and control mice, and linked such changes to effective mobilization of hematopoietic stem/progenitor cells.

RESULTS

We show that granulocyte colony-stimulating factor indirectly reduces expression of surface vascular cell adhesion molecule 1 on bone marrow hematopoietic stem/progenitor cells, stromal cells and endothelial cells by promoting the accumulation of microRNA-126 (miR126)-containing microvescicles in the bone marrow extracellular compartment. We found that hematopoietic stem/progenitor cells, stromal cells and endothelial cells readily incorporate these miR126-loaded microvescicles, and that miR126 represses vascular cell adhesion molecule 1 expression on bone marrow hematopoietic stem/progenitor cells, stromal cells and endothelial cells. In line with this, miR126-null mice displayed a reduced mobilization response to granulocyte colony-stimulating factor.

CONCLUSIONS

Our results implicate miR126 in the regulation of hematopoietic stem/progenitor cell trafficking between the bone marrow and peripheral sites, clarify the role of vascular cell adhesion molecule 1 in granulocyte colony-stimulating factor-mediated mobilization, and have important implications for improved approaches to selective mobilization of hematopoietic stem/progenitor cells.

摘要

背景

粒细胞集落刺激因子（G-CSF）将造血干细胞/祖细胞从骨髓动员到外周血是获取造血细胞移植干细胞移植物的主要手段。由于造血干细胞/祖细胞在 G-CSF 动员的所有血细胞中只占少数，因此需要了解其潜在机制，以便开发选择性药物。

设计与方法

我们分析了 G-CSF 动员和对照小鼠骨髓细胞群体的表型、生化和遗传变化，并将这些变化与造血干细胞/祖细胞的有效动员联系起来。

结果

我们表明，G-CSF 通过促进骨髓细胞外间隙中含有 microRNA-126（miR126）的微泡的积累，间接降低了骨髓造血干细胞/祖细胞、基质细胞和内皮细胞表面血管细胞黏附分子 1 的表达。我们发现造血干细胞/祖细胞、基质细胞和内皮细胞很容易摄取这些含有 miR126 的微泡，而 miR126 抑制了骨髓造血干细胞/祖细胞、基质细胞和内皮细胞表面血管细胞黏附分子 1 的表达。与此一致的是，miR126 缺失小鼠对 G-CSF 的动员反应降低。

结论

我们的结果表明 miR126 参与了造血干细胞/祖细胞在骨髓和外周部位之间的迁移调节，阐明了血管细胞黏附分子 1 在 G-CSF 介导的动员中的作用，对改善造血干细胞/祖细胞的选择性动员方法具有重要意义。