Ohta George, Kobayashi Masato, Sakai Hiroki, Masegi Toshiaki, Yanai Tokuma
Department of Veterinary Pathology, Faculty of Applied Biological Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
J Toxicol Pathol. 2009 Mar;22(1):79-82. doi: 10.1293/tox.22.79. Epub 2009 Apr 6.
The proliferative potential of a spinal nephroblastoma was studied in a young dog. A 4-month-old, female golden retriever showed developing deterioration in her gait and subsequent paralysis of her hind legs. At necropsy, a well-demarcated grayish brown tumor mass was found in the lumbar spinal cord segments between L2 and L3. Histologically, a blastemal cell tumor with a tubule- or glomeruli-like structure was found to be infiltrating intradurally. Proliferating cells at the S-phase, assessed using the bromodeoxyuridine (BrdU) labeling method, were seen occasionally in the tubular cells and glomeruli-like structures and were frequently seen in the blastemal cells. Immunohistochemically, the tubular epithelial cells were positive for cytokeratin, and the blastemal cells were positive for vimentin. The present tumor showed a high potential for growth and invasion, which suggests that it the potential to expand into the adjacent spinal cord.
在一只幼犬身上研究了脊髓肾母细胞瘤的增殖潜能。一只4个月大的雌性金毛寻回犬出现步态逐渐恶化，随后后腿瘫痪。尸检时，在L2和L3之间的腰段脊髓中发现一个边界清楚的灰棕色肿瘤块。组织学检查发现，一个具有小管样或肾小球样结构的母细胞瘤正硬膜内浸润。使用溴脱氧尿苷（BrdU）标记法评估，S期增殖细胞偶尔见于管状细胞和肾小球样结构中，而在母细胞瘤细胞中则经常可见。免疫组化显示，管状上皮细胞细胞角蛋白呈阳性，母细胞瘤细胞波形蛋白呈阳性。目前的肿瘤显示出高生长和侵袭潜能，这表明它有可能扩展至相邻脊髓。
