Numakura Yuki, Konishi Shizuka, Kumabe Shino, Kotera Takashi, Ueda Makoto
Pharmacokinetics and Safety Assessment Department, Nippon Shinyaku Co., Ltd., 14 Nishinosho-monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan.
J Toxicol Pathol. 2020 Oct;33(4):291-295. doi: 10.1293/tox.2020-0013. Epub 2020 Jul 12.
We report a spontaneous case of nephroblastoma in a 26-week-old female Slc:CD(SD) rat. Macroscopically, there was a yellow mass in the left kidney that included another small yellowish-white mass. Histologically, the mass was located mainly in the cortex of the kidney. The tumor showed two distinct morphologies corresponding to the macroscopic findings: a blastemal cell dominant area (blastemal area) with primitive glomeruli and immature tubules and a columnar epithelial tubule dominant area with blastemal cell cuffing on (epithelial area). The epithelial area was located inside the blastemal area and the two morphologies were characterized by the lack of a transition region. Nephroblastoma is known to be biphasic or triphasic and showing transitional features. To our knowledge, there is no report of such nephroblastoma comprising two histologically distinct areas without transition. Therefore, the two distinct morphologies of this case with no transitional characteristic is a rare feature in nephroblastoma.
我们报告了一例26周龄雌性Slc:CD(SD)大鼠自发性肾母细胞瘤病例。大体上，左肾有一个黄色肿块，其中包含另一个淡黄色白色小肿块。组织学上，肿块主要位于肾皮质。肿瘤呈现出与大体所见相对应的两种不同形态：一个以原始肾小球和未成熟肾小管为主的胚基细胞优势区（胚基区），以及一个以柱状上皮小管为主且有胚基细胞套叠的区域（上皮区）。上皮区位于胚基区内，且这两种形态的特征是缺乏过渡区域。已知肾母细胞瘤是双相或三相的，并具有过渡特征。据我们所知，尚无关于这种由两个组织学上不同区域且无过渡的肾母细胞瘤的报道。因此，该病例中这两种无过渡特征的不同形态在肾母细胞瘤中是一种罕见特征。
