• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

7周龄雌性大鼠肝细胞中的自发性铁蓄积。

Spontaneous iron accumulation in hepatocytes of a 7-week-old female rat.

作者信息

Miyata Kaori, Sukata Tokuo, Kushida Masahiko, Ogata Keiko, Suzuki Manabu, Ozaki Masakazu, Ozaki Keisuke, Uwagawa Satoshi

出版信息

J Toxicol Pathol. 2009 Sep;22(3):199-203. doi: 10.1293/tox.22.199. Epub 2009 Oct 15.

DOI:10.1293/tox.22.199
PMID:22271995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3252042/
Abstract

Spontaneous iron accumulation in hepatocytes was observed in a 7-week-old female Han Wistar GALAS rat. Very fine yellowish brown pigments, which showed a positive reaction with Berlin Blue stain, were apparent in the cytoplasm close to the bile canaliculi, with a diminishing periportal-to-centrilobular gradient. There were also differences in distribution between and within lobes. Transmission electron microscopy revealed cytosolic ferritin and pericanalicular siderosomes in hepatocytes. No degeneration or necrotic changes were observed, and non-hepatocyte cells did not demonstrate any obvious accumulation of iron. There were no abnormalities in the animal other than this finding in the liver.

摘要

在一只7周龄的雌性韩系Wistar GALAS大鼠中观察到肝细胞内的自发性铁蓄积。在靠近胆小管的细胞质中可见非常细小的黄褐色色素，其对柏林蓝染色呈阳性反应，门周至中央静脉的梯度逐渐减小。叶间和叶内的分布也存在差异。透射电子显微镜显示肝细胞中有胞质铁蛋白和胆小管周围的含铁小体。未观察到变性或坏死变化，非肝细胞也未显示出明显的铁蓄积。除肝脏的这一发现外，该动物无其他异常。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/3252042/930e18e3c1c5/tox-22-199-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/3252042/c57c2942fe94/tox-22-199-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/3252042/83da8e1f4134/tox-22-199-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/3252042/e3054aa7186f/tox-22-199-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/3252042/930e18e3c1c5/tox-22-199-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/3252042/c57c2942fe94/tox-22-199-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/3252042/83da8e1f4134/tox-22-199-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/3252042/e3054aa7186f/tox-22-199-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/3252042/930e18e3c1c5/tox-22-199-g004.jpg

相似文献

1
Spontaneous iron accumulation in hepatocytes of a 7-week-old female rat.7周龄雌性大鼠肝细胞中的自发性铁蓄积。
J Toxicol Pathol. 2009 Sep;22(3):199-203. doi: 10.1293/tox.22.199. Epub 2009 Oct 15.
2
Ultrastructural sequences during liver iron overload in genetic hemochromatosis.遗传性血色素沉着症肝脏铁过载时的超微结构变化序列
J Hepatol. 1997 Oct;27(4):628-38. doi: 10.1016/s0168-8278(97)80079-7.
3
Spontaneous iron overload in Sprague-Dawley rats.斯普拉格-道利大鼠的自发性铁过载
Toxicol Pathol. 1997 May-Jun;25(3):308-16. doi: 10.1177/019262339702500308.
4
Pathologic changes in the cytokeratin pericanalicular sheath in experimental cholestasis and alcoholic fatty liver.实验性胆汁淤积和酒精性脂肪肝中细胞角蛋白小管周围鞘的病理变化
Lab Invest. 1988 Jul;59(1):60-74.
5
Iron overload of the liver in the baboon. An ultrastructural study.狒狒肝脏铁过载的超微结构研究
J Hepatol. 1985;1(3):261-75. doi: 10.1016/s0168-8278(85)80054-4.
6
Iron distribution in the liver and duodenum during seasonal iron overload in Svalbard reindeer.斯瓦尔巴德驯鹿季节性铁过载期间肝脏和十二指肠中的铁分布
J Comp Pathol. 2009 Jul;141(1):27-40. doi: 10.1016/j.jcpa.2009.02.001. Epub 2009 Apr 3.
7
Studies of iron overload. Rat liver siderosome ferritin.铁过载研究。大鼠肝脏铁小体铁蛋白。
Lab Invest. 1984 Jan;50(1):26-35.
8
Characterization and accumulation of ferritin in hepatocyte nuclei of mice with iron overload.
Hepatology. 1990 Dec;12(6):1399-405. doi: 10.1002/hep.1840120622.
9
Ultrastructure of the intracellular membranous system of rat hepatocytes in intrahepatic cholestasis induced by phalloidin.鬼笔环肽诱导的大鼠肝内胆汁淤积时肝细胞内膜系统的超微结构
J Hepatol. 1994 Oct;21(4):560-6. doi: 10.1016/s0168-8278(94)80101-0.
10
Iron overload of the bone marrow by trimethylhexanoyl-ferrocene in rats.大鼠中三甲基己酰基二茂铁导致的骨髓铁过载
Acta Anat (Basel). 1992;144(4):285-95. doi: 10.1159/000147318.

引用本文的文献

1
A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2.一种因转铁蛋白受体2突变导致的遗传性血色素沉着症的新型大鼠模型。
Comp Med. 2013 Apr;63(2):143-55.
2
Background Data for General Toxicology Parameters in RccHan:WIST Rats at 8, 10, 19 and 32 Weeks of Age.RccHan:WIST大鼠在8周、10周、19周和32周龄时一般毒理学参数的背景数据。
J Toxicol Pathol. 2011 Dec;24(4):195-205. doi: 10.1293/tox.24.195. Epub 2012 Jan 7.

本文引用的文献

1
Iron overload syndromes and the liver.铁过载综合征与肝脏
Mod Pathol. 2007 Feb;20 Suppl 1:S31-9. doi: 10.1038/modpathol.3800715.
2
Iron-rich foci in chronic viral hepatitis.慢性病毒性肝炎中的富铁灶。
Hum Pathol. 1998 Feb;29(2):116-8. doi: 10.1016/s0046-8177(98)90219-2.
3
Ultrastructural sequences during liver iron overload in genetic hemochromatosis.遗传性血色素沉着症肝脏铁过载时的超微结构变化序列
J Hepatol. 1997 Oct;27(4):628-38. doi: 10.1016/s0168-8278(97)80079-7.
4
Spontaneous iron overload in Sprague-Dawley rats.斯普拉格-道利大鼠的自发性铁过载
Toxicol Pathol. 1997 May-Jun;25(3):308-16. doi: 10.1177/019262339702500308.
5
Histopathological evaluation of liver, pancreas, spleen, and heart from iron-overloaded Sprague-Dawley rats.对铁过载的斯普拉格-道利大鼠的肝脏、胰腺、脾脏和心脏进行组织病理学评估。
Toxicol Pathol. 1996 Sep-Oct;24(5):558-63. doi: 10.1177/019262339602400504.
6
Uneven hepatic iron and phosphorus distribution in beta-thalassemia.β地中海贫血患者肝脏中铁和磷分布不均。
J Hepatol. 1995 Nov;23(5):544-9. doi: 10.1016/0168-8278(95)80060-3.
7
Regulation of iron metabolism in HepG2 cells: a possible role for cytokines in the hepatic deposition of iron.
Hepatology. 1993 Oct;18(4):874-80. doi: 10.1002/hep.1840180420.
8
Absence of stainable iron from preneoplastic and neoplastic lesions in rat liver with 8-hydroxyquinoline-induced siderosis.8-羟基喹啉诱导大鼠肝脏铁沉着症时，癌前病变和肿瘤病变中无可染铁。
J Natl Cancer Inst. 1972 Sep;49(3):685-92.
9
Biochemical and biophysical investigations of the ferrocene-iron-loaded rat. An animal model of primary haemochromatosis.对二茂铁-铁负载大鼠的生物化学和生物物理研究。原发性血色素沉着症的动物模型。
Eur J Biochem. 1991 Dec 5;202(2):405-10. doi: 10.1111/j.1432-1033.1991.tb16389.x.
10
Alterations in tissue ferritins in iron storage disorders.铁储存障碍中组织铁蛋白的改变。
Gut. 1975 Nov;16(11):909-12. doi: 10.1136/gut.16.11.909.