十一酸睾酮长效注射剂中苯甲酸苄酯引发的过敏反应。
Anaphylaxis triggered by benzyl benzoate in a preparation of depot testosterone undecanoate.
作者信息
Ong Gregory S Y, Somerville Colin P, Jones Timothy W, Walsh John P
机构信息
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, 1st Floor, C-Block, Hospital Avenue, Nedlands, WA 6009, Australia.
出版信息
Case Rep Med. 2012;2012:384054. doi: 10.1155/2012/384054. Epub 2012 Jan 5.
We report the first case of an anaphylactic reaction to Reandron 1000 (depot testosterone undecanoate with a castor oil and benzyl benzoate vehicle). While considered to have a favourable safety profile, serious complications such as oil embolism and anaphylaxis can occur. In our patient, skin testing identified benzyl benzoate to be the trigger, with no reaction to castor oil or testosterone undecanoate components. As benzyl benzoate exists in multiple pharmaceuticals, foods, and cosmetics, individual components of pharmaceuticals should be tested when investigating drug allergies. Doctors should be alert to the potential for serious reactions to any of the components of Reandron 1000.
我们报告了首例对Reandron 1000（十一酸睾酮注射液，含蓖麻油和苯甲酸苄酯辅料）发生过敏反应的病例。尽管该药被认为具有良好的安全性，但仍可能发生油栓和过敏反应等严重并发症。在我们的患者中，皮肤试验确定苯甲酸苄酯为引发因素，对蓖麻油或十一酸睾酮成分无反应。由于苯甲酸苄酯存在于多种药品、食品和化妆品中，在调查药物过敏时应检测药品的各个成分。医生应警惕Reandron 1000任何成分发生严重反应的可能性。
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