Pellissier P E, David A, Coppéré H, Barthélémy C, Cuilleret J, Boucheron S, Claudy A, Audigier J C
Service de Gastroentérologie et d'Hépatologie, CHU Saint-Etienne Nord, Saint-Priest-en-Jarez.
Gastroenterol Clin Biol. 1990;14(8-9):672-4.
A 61-year-old man developed primary adenocarcinoma with skin invasion, at the ileostomy site 33 years after a proctocolectomy for ulcerative colitis. A total of eleven patients with ileostomy adenocarcinoma have been reported in the literature. Ten patients were treated surgically for ulcerative colitis and the other for adenomatous polyposis coli. The diagnosis of stomal malignancy was made 9 to 36 years after the ileostomy (mean interval, 22 years). The pathogenesis of the malignant growth is uncertain and several possibilities are discussed: stasis, severe chronic inflammation, colonic metaplasia and severe dysplasia of the ileal mucosa. When an ileostomy requires late revision for inflammatory changes, careful pathologic examination of the entire stoma and surrounding skin is essential.
一名61岁男性在因溃疡性结肠炎行直肠结肠切除术后33年，在回肠造口部位发生了侵犯皮肤的原发性腺癌。文献中总共报道了11例回肠造口腺癌患者。10例患者因溃疡性结肠炎接受手术治疗，另1例因家族性腺瘤性息肉病接受手术治疗。造口恶性肿瘤的诊断在回肠造口术后9至36年作出（平均间隔22年）。恶性生长的发病机制尚不确定，讨论了几种可能性：淤滞、严重慢性炎症、结肠化生和回肠黏膜的严重发育异常。当回肠造口因炎症变化需要后期修复时，对整个造口和周围皮肤进行仔细的病理检查至关重要。
