Starke J, Rodriguez-Bigas M, Marshall W, Sohrabi A, Petrelli N J
Roswell Park Cancer Institute, Buffalo, N.Y.
Surgery. 1993 Jul;114(1):125-8.
Two cases are added to the world literature of patients in whom an adenocarcinoma developed at the ileostomy site after total proctocolectomy for ulcerative colitis. Fourteen additional cases have been reported in the world literature; of these, 12 cases have been in patients with ulcerative colitis, and four cases have been in patients with familial adenomatous polyposis. Adenocarcinoma of an ileostomy is not common. However, in the analysis of the reported cases, patients with long-standing ileostomies appear to be at a greater risk. With an aging ileostomy population, an increase in the number of cases may be seen. Three hypotheses are discussed as potential causative pathways to this entity. Continued analysis of these cases may yield information on the pathophysiology involved.
世界文献中新增了两例在溃疡性结肠炎全直肠结肠切除术后回肠造口部位发生腺癌的患者病例。世界文献中还报道了另外14例；其中，12例为溃疡性结肠炎患者，4例为家族性腺瘤性息肉病患者。回肠造口腺癌并不常见。然而，在对已报道病例的分析中，长期存在回肠造口的患者似乎风险更大。随着回肠造口人群的老龄化，病例数量可能会增加。文中讨论了三种假设作为该疾病潜在的致病途径。对这些病例的持续分析可能会得出有关所涉及病理生理学的信息。
