卡宾迁移插入反应生成的环丙甲基钯物种：制备 1,3-丁二烯的新途径。

Cyclopropylmethyl palladium species from carbene migratory insertion: new routes to 1,3-butadienes.

机构信息

Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.

出版信息

Org Lett. 2012 Feb 3;14(3):922-5. doi: 10.1021/ol2034405. Epub 2012 Jan 24.

DOI:10.1021/ol2034405

PMID:22272799

Abstract

Cyclopropylmethyl palladium species can be accessed by Pd-catalyzed reaction of either cyclopropyl N-tosylhydrazone with halide or N-tosylhydrazone with cyclopropyl halide. In both approaches migratory insertion of Pd carbene is the key process. These transformations constitute new approaches toward 1,3-butadiene derivatives.

摘要

通过钯催化反应，无论是环丙基 N-对甲苯磺酰腙与卤化物反应，还是 N-对甲苯磺酰腙与环丙基卤化物反应，都可以得到环丙甲基钯物种。在这两种方法中，Pd 卡宾的迁移插入是关键过程。这些转化构成了制备 1,3-丁二烯衍生物的新方法。