Center for Molecular Imaging, Department of Chemistry IFM, University of Torino, via Nizza 52, Torino, Italy.
Chem Commun (Camb). 2012 Feb 28;48(18):2436-8. doi: 10.1039/c2cc17801j. Epub 2012 Jan 25.
Mn(III)-loaded apoferritin is promptly reduced to Mn(II)-apoferritin by the oxidation of L-DOPA to melanin. The process is nicely witnessed by a marked relaxation enhancement of water proton relaxation rate that has been detected both in cultured melanoma cells and in tumor animal models.
载锰（III）脱铁蛋白被 L-多巴氧化为黑色素，迅速还原为载锰（II）脱铁蛋白。这一过程在培养的黑色素瘤细胞和肿瘤动物模型中均检测到水质子弛豫率的明显增强，很好地证明了这一点。
