Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QZ, UK.
Chem Commun (Camb). 2013 Oct 28;49(84):9704-21. doi: 10.1039/c3cc44268c.
Biomedical imaging techniques can provide a vast amount of anatomical information, enabling diagnosis and the monitoring of disease and treatment profile. MRI uniquely offers convenient, non-invasive, high resolution tomographic imaging. A considerable amount of effort has been invested, across several decades, in the design of non toxic paramagnetic contrast agents capable of enhancing positive MRI signal contrast. Recently, focus has shifted towards the development of agents capable of specifically reporting on their local biochemical environment, where a switch in image contrast is triggered by a specific stimulus/biochemical variable. Such an ability would not only strengthen diagnosis but also provide unique disease-specific biochemical insight. This feature article focuses on recent progress in the development of MRI contrast switching with molecular, macromolecular and nanoparticle-based agents.
生物医学成像技术可以提供大量的解剖学信息，有助于诊断和监测疾病及治疗过程。磁共振成像（MRI）具有独特的优势，能够提供便捷、非侵入性、高分辨率的断层成像。几十年来，人们投入了大量精力来设计能够增强 MRI 信号对比度的无毒顺磁对比剂。最近，研究重点转向了开发能够专门报告局部生化环境的试剂，通过特定的刺激/生化变量来触发图像对比度的切换。这种能力不仅可以加强诊断，还可以提供独特的疾病特异性生化见解。本文重点介绍了基于分子、大分子和纳米颗粒的 MRI 对比切换试剂的最新进展。
