Clerget-Darpoux F, Babron M C, Bonaïti-Pellié C
INSERM U155, Paris, France.
Genet Epidemiol. 1990;7(4):245-53. doi: 10.1002/gepi.1370070403.
The significance of a lod score value of 3 is very difficult to assess in linkage studies between a genetic marker and a complex disease. One reason is that multiple tests may have been performed, voluntarily or otherwise. For the same disease, linkage may be tested by different laboratories with several markers under various genetic models and diagnostic schemes for the disease. In such a case, we show that the probability of getting a lod score value of 3 under independent transmission of the disease and the marker may be not negligible.
在基因标记与复杂疾病之间的连锁研究中，对数优势比分值为3的意义很难评估。一个原因是可能已经进行了多次测试，不管是自愿的还是其他情况。对于同一种疾病，不同实验室可能会在各种遗传模型和疾病诊断方案下，用几种标记来测试连锁情况。在这种情况下，我们表明在疾病和标记独立传递的情况下，获得对数优势比分值为3的概率可能不可忽略。
