利用一组标记基因座对连锁lod分数进行解读。
Interpretation of LOD scores with a set of marker loci.
作者信息
Thompson E A
出版信息
Genet Epidemiol. 1984;1(4):357-62. doi: 10.1002/gepi.1370010407.
PMID:6599404
Abstract
The problem discussed is that of interpreting LOD scores when multiple markers are tested for linkage with a particular disease locus. Provided the tests are based on independent segregations, both the maximum and the average LOD can be translated into a score that would have the same significance level were it the result of a single test.
摘要
所讨论的问题是，当对多个标记进行与特定疾病位点的连锁测试时，如何解读LOD分数。假设测试基于独立分离，那么最大LOD分数和平均LOD分数都可以转化为一个分数，该分数如果是单次测试的结果，将会具有相同的显著性水平。
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