Academic Surgical Unit, Barts and The London NHS Trust, Queen Mary University of London, London, UK.
Int J Colorectal Dis. 2012 Jul;27(7):927-30. doi: 10.1007/s00384-011-1405-3. Epub 2012 Jan 25.
Percutaneous tibial nerve stimulation (PTNS) is an acceptable second line treatment for patients with faecal incontinence (FI) unresponsive to conservative measures. There is however a paucity of data in the literature regarding its efficacy. The aim of this prospective study was to evaluate the efficacy of PTNS in an exclusively female cohort of patients and to identify factors that may predict treatment response.
A prospective cohort of female patients with FI underwent evaluation of sphincter morphology, anorectal pressures and rectal sensation as part of their physiologic assessment prior to treatment. PTNS was performed according to a specific departmental protocol. The clinical outcomes measured were: (1) Cleveland Clinic incontinence scores, (2) deferment time and (3) weekly incontinence episodes. Outcomes were compared at baseline and following treatment using appropriate statistical tests. Clinical outcomes were correlated with the results of the anorectal physiology testing (i.e. sphincter morphology, rectal sensation).
Eighty-eight female patients with a mean age of 58.0 ± 13.6 years were included in the analysis. FI was predominantly a late consequence of obstetric injury. The mean incontinence score improved from 12.2 ± 4.0 at baseline to 9.1 ± 4.6 following treatment (p < 0.0001). Statistically significant improvements were also seen in the median deferment time and median number of weekly incontinence episodes. Sphincter damage and altered rectal sensation did not appear to influence the outcomes.
PTNS is an effective treatment in female patients with FI. Improvements in clinical outcomes were independent of damage to the anal sphincter complex in patients with normal rectal sensation.
经皮胫神经刺激(PTNS)是一种可接受的二线治疗方法,适用于对保守治疗无反应的粪便失禁(FI)患者。然而,文献中关于其疗效的数据很少。本前瞻性研究的目的是评估 PTNS 在纯女性队列患者中的疗效,并确定可能预测治疗反应的因素。
一组患有 FI 的女性患者在接受治疗前接受了肛门直肠形态、压力和直肠感觉的生理评估。PTNS 根据特定的部门方案进行。测量的临床结果包括:(1)克利夫兰诊所失禁评分,(2)延迟时间和(3)每周失禁发作次数。使用适当的统计检验比较治疗前后的结果。临床结果与肛门直肠生理学测试(即括约肌形态、直肠感觉)的结果相关。
88 名平均年龄为 58.0 ± 13.6 岁的女性患者被纳入分析。FI 主要是产科损伤的晚期后果。失禁评分从基线时的 12.2 ± 4.0 平均改善至治疗后的 9.1 ± 4.6(p < 0.0001)。中位数延迟时间和每周失禁发作次数也有显著改善。括约肌损伤和直肠感觉改变似乎并不影响结果。
PTNS 是 FI 女性患者的有效治疗方法。在直肠感觉正常的患者中,临床结果的改善与肛门括约肌复合体的损伤无关。