Department of Military Hygiene, Second Military Medical University, Shanghai, China.
Biol Trace Elem Res. 2012 Jun;147(1-3):285-91. doi: 10.1007/s12011-011-9319-z. Epub 2012 Jan 25.
Psychological stress (PS) could cause decreased iron absorption and iron redistribution in body resulting in low iron concentration in the bone marrow and inhibition of erythropoiesis. In the present study, we investigated the effect of zinc supplementation on the iron metabolism, erythropoiesis, and oxidative stress status in PS-induced rats. Thirty-two rats were divided into two groups randomly: control group and zinc supplementation group. Each group was subdivided into two subgroups: control group and PS group. Rats received zinc supplementation before PS exposure established by a communication box. We investigated the serum corticosterone (CORT) level; iron apparent absorption; iron contents in liver, spleen, cortex, hippocampus, striatum, and serum; hematological parameters; malondialdehyde (MDA); reduced glutathione (GSH); and superoxide dismutase (SOD). Compared to PS-treated rats with normal diet, the PS-treated rats with zinc supplementation showed increased iron apparent absorption, serum iron, hemoglobin, red blood cell, GSH, and SOD activities; while the serum CORT; iron contents in liver, spleen, and regional brain; and MDA decreased. These results indicated that dietary zinc supplementation had preventive effects against PS-induced iron dyshomeostasis, erythropoiesis inhibition, and oxidative stress status in rats.
心理应激（PS）可导致体内铁吸收减少和铁重新分布，从而导致骨髓中铁浓度降低和红细胞生成抑制。在本研究中，我们研究了补锌对 PS 诱导大鼠铁代谢、红细胞生成和氧化应激状态的影响。32 只大鼠随机分为两组：对照组和补锌组。每组又分为两个亚组：对照组和 PS 组。大鼠在通过交流盒建立 PS 暴露前接受补锌。我们检测了血清皮质酮（CORT）水平；铁表观吸收率；肝、脾、皮质、海马、纹状体和血清中铁含量；血液学参数；丙二醛（MDA）；还原型谷胱甘肽（GSH）；和超氧化物歧化酶（SOD）。与正常饮食的 PS 处理大鼠相比，补锌的 PS 处理大鼠表现出铁表观吸收率、血清铁、血红蛋白、红细胞、GSH 和 SOD 活性增加；而血清 CORT；肝、脾和区域性脑铁含量；和 MDA 降低。这些结果表明，膳食补锌对大鼠 PS 诱导的铁代谢失衡、红细胞生成抑制和氧化应激状态具有预防作用。
