Cheng Yongqing, You Shuangfei, Wang Xin, Ge Yingchao, Li Lei, Ren Taojie, Chen Songjie, He Guojun, Xue Shouru
Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Front Neurosci. 2025 Aug 28;19:1620118. doi: 10.3389/fnins.2025.1620118. eCollection 2025.
Insulin resistance (IR) is proved be involved in the pathophysiology of Parkinson's disease (PD). As an effective surrogate marker of IR, the correlation between the triglyceride-glucose (TyG) index and PD remains unclear. This cross-sectional study aimed to explore the association between the TyG index and cognitive impairment in PD (PDCI).
Patients with sporadic PD were consecutively enrolled between May 2022 and October 2023. The cognitive function was evaluated using the Montreal Cognitive Assessment (MoCA). The Spearman correlation analysis was used to evaluate the correlation between TyG index and MoCA score, Unified-Parkinson Disease Rating Scale (UPDRS) III and peripheral blood oxidative stress markers, respectively. Logistic regression analysis was performed to explore the correlation between TyG and PDCI and dementia in PD (PDD).
A total of 78 patients were enrolled, of whom 50 (64.1%) were diagnosed with PDCI [26 with mild cognitive impairment (MCI) and 24 with PDD]. The TyG index in patients with dementia and MCI were higher than those with normal cognition (9.32 ± 0.43 vs. 8.90 ± 0.47 vs. 8.51 ± 0.46, < 0.001). The Spearman correlation analysis demonstrated that TyG was negatively correlated with MoCA ( = -0.704, < 0.001) and superoxide dismutase ( = -0.244, = 0.031), but positively correlated with UPDRS III ( = 0.246, = 0.030). Multivariate logistic regression analysis showed that TyG was independently associated with PDCI regardless of whether it was used as a continuous variable (OR = 6.177, 95% CI = 1.590-24.000) or a tertile variable (OR = 5.478, 95% CI = 1.030-29.132). This association persisted after excluding patients with diabetes. The receiver operating characteristic (ROC) analysis suggested that the area under the curve (AUC) of TyG for predicting PDCI was 0.805 (95% CI = 0.707-0.903, < 0.001).
Elevated TyG levels were associated with an increased likelihood of PDCI in patients with PD.
胰岛素抵抗（IR）被证实参与帕金森病（PD）的病理生理过程。作为IR的有效替代标志物，甘油三酯-葡萄糖（TyG）指数与PD之间的相关性仍不明确。这项横断面研究旨在探讨TyG指数与PD认知障碍（PDCI）之间的关联。
2022年5月至2023年10月连续纳入散发性PD患者。使用蒙特利尔认知评估量表（MoCA）评估认知功能。分别采用Spearman相关性分析评估TyG指数与MoCA评分、统一帕金森病评定量表（UPDRS）Ⅲ以及外周血氧化应激标志物之间的相关性。进行逻辑回归分析以探讨TyG与PDCI及PD痴呆（PDD）之间的相关性。
共纳入78例患者，其中50例（64.1%）被诊断为PDCI[26例轻度认知障碍（MCI）和24例PDD]。痴呆和MCI患者的TyG指数高于认知正常者（9.32±0.43 vs. 8.90±0.47 vs. 8.51±0.46，<0.001）。Spearman相关性分析表明，TyG与MoCA呈负相关（=-0.704，<0.001），与超氧化物歧化酶呈负相关（=-0.244，=0.031），但与UPDRSⅢ呈正相关（=0.246，=0.030）。多因素逻辑回归分析显示，无论TyG作为连续变量（OR=6.177，95%CI=1.590-24.000）还是三分位数变量（OR=5.478，95%CI=1.030-29.132），TyG均与PDCI独立相关。排除糖尿病患者后，这种关联仍然存在。受试者工作特征（ROC）分析表明，TyG预测PDCI的曲线下面积（AUC）为0.805（95%CI=0.707-0.903，<0.001）。
PD患者中TyG水平升高与发生PDCI的可能性增加相关。
