Morgan G
Welsh Aspirin Group Secretary, 41 Fforrd Beck, Gowerton, Swansea, Wales SA4 3GE, UK.
Ecancermedicalscience. 2008;2:100. doi: 10.3332/ecancer.2008.100. Epub 2008 Nov 12.
Chemoprevention describes the potential of chemicals to intervene and block multi-stage carcinogenesis. Aspirin (acetylsalicylate) is showing cancer chemopreventive potential and the medicine has public health potential given that low doses also reduce the risk of cardiovascular events by up to 30%. Whilst recognizing that aspirin has undesirable effects, such as increasing the risk of stomach bleeding, perhaps the medicine may compliment other cancer control programmes such as screening and lifestyle measures. Furthermore, perhaps the cancer chemopreventive potential of aspirin might be mediated, at least in part, by salicylate, which is present in fruits and vegetables. Salicylate might, therefore, be considered to be a nutraceutical. Furthermore, there are a number of matters that arise including the potential for the public health field to further advocate the self-care preventive agenda, which might include aspirin. Perhaps, it is now timely for a conference on the public health potential of aspirin to be convened.
化学预防描述了化学物质干预和阻断多阶段致癌过程的潜力。阿司匹林（乙酰水杨酸）显示出癌症化学预防潜力，鉴于低剂量阿司匹林还能将心血管事件风险降低多达30%，该药具有公共卫生潜力。虽然认识到阿司匹林有不良影响，如增加胃出血风险，但该药或许可以补充其他癌症控制项目，如筛查和生活方式措施。此外，阿司匹林的癌症化学预防潜力可能至少部分由水果和蔬菜中含有的水杨酸介导。因此，水杨酸可能被视为一种营养保健品。此外，还出现了一些问题，包括公共卫生领域进一步倡导自我保健预防议程（可能包括阿司匹林）的可能性。或许，现在召开一次关于阿司匹林公共卫生潜力的会议恰逢其时。
