• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

细胞间融合作为癌症治疗的潜在靶点。

Cell-cell fusion as a potential target in cancer therapy.

作者信息

Gasent Blesa Jm, Candel Va

机构信息

Hospital General Universitari Marina Alta, Denia, Plana de l'Est no 5, Alacant, Spain.

出版信息

Ecancermedicalscience. 2009;3:145. doi: 10.3332/ecancer.2009.145. Epub 2009 Aug 6.

DOI:10.3332/ecancer.2009.145
PMID:22276010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3224012/
Abstract

In the fight against cancer, new and more specific targets are needed. Here, we offer an example of a potential target that has not been widely studied, namely the syncytin protein. Syncytin is expressed mainly in the human placenta and is implicated in placental syncytiotrophoblast cell fusion. Not much is known about the role of syncytin in cancer, but the existing data call for more intense research. Its retroviral origin and particular tissue distribution make syncytin an interesting potential target in cancer therapy.

摘要

在对抗癌症的斗争中，需要新的、更具特异性的靶点。在此，我们提供一个尚未得到广泛研究的潜在靶点的例子，即合胞素蛋白。合胞素主要在人胎盘中表达，并与胎盘合体滋养层细胞融合有关。关于合胞素在癌症中的作用知之甚少，但现有数据表明需要进行更深入的研究。其逆转录病毒起源和特殊的组织分布使合胞素成为癌症治疗中一个有趣的潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54dc/3224012/beea1c81030f/can-3-145f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54dc/3224012/beea1c81030f/can-3-145f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54dc/3224012/beea1c81030f/can-3-145f1.jpg

相似文献

1
Cell-cell fusion as a potential target in cancer therapy.细胞间融合作为癌症治疗的潜在靶点。
Ecancermedicalscience. 2009;3:145. doi: 10.3332/ecancer.2009.145. Epub 2009 Aug 6.
2
A Cell Fusion-Based Screening Method Identifies Glycosylphosphatidylinositol-Anchored Protein Ly6e as the Receptor for Mouse Endogenous Retroviral Envelope Syncytin-A.一种基于细胞融合的筛选方法鉴定出糖基磷脂酰肌醇锚定蛋白Ly6e作为小鼠内源性逆转录病毒包膜蛋白Syncytin-A的受体。
J Virol. 2017 Aug 24;91(18). doi: 10.1128/JVI.00832-17. Print 2017 Sep 15.
3
A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast.一对共转导的逆转录病毒包膜基因syncytin 对于形成双层鼠胎盘合胞滋养层是必需的。
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1164-73. doi: 10.1073/pnas.1112304108. Epub 2011 Oct 27.
4
Identification of an endogenous retroviral envelope gene with fusogenic activity and placenta-specific expression in the rabbit: a new "syncytin" in a third order of mammals.鉴定兔体内一种具有融合活性和胎盘特异性表达的内源性逆转录病毒包膜基因：第三类哺乳动物中的一种新的“合胞素”。
Retrovirology. 2009 Nov 27;6:107. doi: 10.1186/1742-4690-6-107.
5
GCMa regulates the syncytin-mediated trophoblastic fusion.巨细胞融合相关蛋白A调节合胞素介导的滋养层融合。
J Biol Chem. 2002 Dec 20;277(51):50062-8. doi: 10.1074/jbc.M209316200. Epub 2002 Oct 22.
6
Syncytin-A mediates the formation of syncytiotrophoblast involved in mouse placental development.合胞素-A介导参与小鼠胎盘发育的合体滋养层细胞的形成。
Cell Physiol Biochem. 2007;20(5):517-26. doi: 10.1159/000107535.
7
Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene.合胞素A基因敲除小鼠证明了一种融合性、内源性逆转录病毒衍生的包膜基因在胎盘形成中的关键作用。
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12127-32. doi: 10.1073/pnas.0902925106. Epub 2009 Jun 29.
8
The captured retroviral envelope syncytin-A and syncytin-B genes are conserved in the Spalacidae together with hemotrichorial placentation.捕获的逆转录病毒包膜蛋白合胞素-A和合胞素-B基因在竹鼠科中与血绒毛膜胎盘一起保守存在。
Biol Reprod. 2014 Dec;91(6):148. doi: 10.1095/biolreprod.114.124818. Epub 2014 Oct 22.
9
Functional characterization of syncytin-A, a newly murine endogenous virus envelope protein. Implication for its fusion mechanism.新型小鼠内源性病毒包膜蛋白合胞素-A的功能特性。对其融合机制的启示。
J Biol Chem. 2007 Jan 5;282(1):381-9. doi: 10.1074/jbc.M606353200. Epub 2006 Nov 14.
10
Regulation of murine placentogenesis by the retroviral genes Syncytin-A, Syncytin-B and Peg10.逆转录病毒基因 Syncytin-A、Syncytin-B 和 Peg10 对鼠类胎盘发生的调控。
Differentiation. 2013 Apr-Jun;85(4-5):150-60. doi: 10.1016/j.diff.2013.02.002. Epub 2013 Jun 25.

引用本文的文献

1
COVID-19. Biology, pathophysiology, and immunology: a pathologist view.新型冠状病毒肺炎（COVID-19）的生物学、病理生理学和免疫学：病理学家的视角。
Pathologica. 2023 Oct;115(5):248-256. doi: 10.32074/1591-951X-954.
2
The role of human endogenous retroviruses in gliomas: from etiological perspectives and therapeutic implications.人类内源性逆转录病毒在神经胶质瘤中的作用：从病因学角度和治疗意义来看。
Neuro Oncol. 2021 Oct 1;23(10):1647-1655. doi: 10.1093/neuonc/noab142.
3
Bladder Cancer Stem-Like Cells: Their Origin and Therapeutic Perspectives.膀胱癌干细胞样细胞：其起源与治疗前景

本文引用的文献

1
Cell fusions in mammals.哺乳动物中的细胞融合。
Histochem Cell Biol. 2008 May;129(5):551-61. doi: 10.1007/s00418-008-0411-1. Epub 2008 Mar 20.
2
Prognostic role of syncytin expression in breast cancer.合胞素表达在乳腺癌中的预后作用。
Hum Pathol. 2007 May;38(5):726-31. doi: 10.1016/j.humpath.2006.10.018. Epub 2007 Feb 15.
3
Proliferation and cell-cell fusion of endometrial carcinoma are induced by the human endogenous retroviral Syncytin-1 and regulated by TGF-beta.人内源性逆转录病毒Syncytin-1可诱导子宫内膜癌的增殖和细胞间融合，并受转化生长因子-β调控。
Int J Mol Sci. 2015 Dec 29;17(1):43. doi: 10.3390/ijms17010043.
J Mol Med (Berl). 2007 Jan;85(1):23-38. doi: 10.1007/s00109-006-0104-y. Epub 2006 Oct 26.
4
Syncytin is involved in breast cancer-endothelial cell fusions.合胞素参与乳腺癌-内皮细胞融合。
Cell Mol Life Sci. 2006 Aug;63(16):1906-11. doi: 10.1007/s00018-006-6201-9.
5
CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues.CpG甲基化抑制人内源性逆转录病毒包膜糖蛋白1在非胎盘组织中的转录活性。
Exp Cell Res. 2006 Apr 15;312(7):1011-20. doi: 10.1016/j.yexcr.2005.12.010. Epub 2006 Jan 20.
6
The gene of retroviral origin Syncytin 1 is specific to hominoids and is inactive in Old World monkeys.源自逆转录病毒的合胞素1基因是类人猿特有的，在旧世界猴中不活跃。
J Hered. 2006 Mar-Apr;97(2):100-6. doi: 10.1093/jhered/esj011. Epub 2006 Jan 19.
7
Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates.人内源性逆转录病毒合胞素-2关键结构域的晶体结构，合胞素-2是一种4000万年前被灵长类动物捕获的内源性逆转录病毒融合包膜基因。
J Mol Biol. 2005 Oct 7;352(5):1029-34. doi: 10.1016/j.jmb.2005.07.058.
8
Biological implications of cell fusion.细胞融合的生物学意义。
Nat Rev Mol Cell Biol. 2005 Jul;6(7):567-75. doi: 10.1038/nrm1678.
9
A placenta-specific enhancer of the human syncytin gene.人类合胞素基因的胎盘特异性增强子。
Biol Reprod. 2005 Sep;73(3):500-9. doi: 10.1095/biolreprod.105.039941. Epub 2005 May 11.
10
Functional characterization of two newly identified Human Endogenous Retrovirus coding envelope genes.两个新鉴定出的人类内源性逆转录病毒编码包膜基因的功能特性
Retrovirology. 2005 Mar 14;2:19. doi: 10.1186/1742-4690-2-19.