Discipline of Infectious Diseases and Immunology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Exp Dermatol. 2012 Apr;21(4):241-8. doi: 10.1111/j.1600-0625.2012.01438.x. Epub 2012 Jan 26.
Ultraviolet (UV) radiation contained in sunlight is considered a major risk in the induction of skin cancer. While mast cells are best known for their role in allergic responses, they have also been shown to play a crucial role in suppressing the anti-tumour immune response following UV exposure. Evidence is now emerging that UV may also trigger mast cell release of cutaneous tissue remodelling and pro-angiogenic factors. In this review, we will focus on the cellular and molecular mechanisms by which UV recruits and then activates mast cells to initiate and promote skin cancer development.
阳光中的紫外线（UV）辐射被认为是诱发皮肤癌的主要风险因素。虽然肥大细胞以其在过敏反应中的作用而闻名，但它们在抑制 UV 暴露后抗肿瘤免疫反应方面也发挥着至关重要的作用。现在有证据表明，UV 还可能触发肥大细胞释放皮肤组织重塑和促血管生成因子。在这篇综述中，我们将重点讨论 UV 招募并激活肥大细胞以启动和促进皮肤癌发展的细胞和分子机制。
