Streilein J W, Taylor J R, Vincek V, Kurimoto I, Shimizu T, Tie C, Golomb C
Schepens Eye Research Institute, Boston, MA 02114.
Immunol Today. 1994 Apr;15(4):174-9. doi: 10.1016/0167-5699(94)90315-8.
Immune surveillance poses the existence of a recirculating pool of lymphocytes that migrate randomly through somatic tissues. Upon recognition of neoantigens on malignantly transformed cells, lymphocytes proceed to attack and destroy degenerate cells before a tumor emerges. Here, J. Wayne Streilein and colleagues review the effects of ultraviolet B irradiation on the induction of cutaneous immunity in the skin of mice and humans. Furthermore, they discuss the possibility of a genetic predisposition to skin cancer, mediated by a defect in the normal process by which contact hypersensitivity, and therefore immunogenicity, is elicited.
免疫监视意味着存在一个循环的淋巴细胞池，它们随机迁移穿过体细胞组织。一旦识别出恶性转化细胞上的新抗原，淋巴细胞就会在肿瘤出现之前攻击并破坏退化细胞。在此，J. 韦恩·施特赖林及其同事回顾了紫外线B照射对小鼠和人类皮肤中皮肤免疫诱导的影响。此外，他们还讨论了由接触性超敏反应进而引发免疫原性的正常过程缺陷介导的皮肤癌遗传易感性的可能性。
