Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
DNA Cell Biol. 2012 Jun;31(6):988-92. doi: 10.1089/dna.2011.1471. Epub 2012 Jan 25.
Schizophrenia is a severe psychiatric disorder. Although its exact cause is unknown, it is widely accepted that environmental factors and genes integrate in the pathogenesis of schizophrenia. 19q13, which contains IL-28B, is a newly identified potential susceptibility locus. IL-28B is a cytokine that functionally has anti-viral activity, but, structurally, is related to the interleukin-10 family. Both virus infection and cytokine changes have been documented in schizophrenia. We selected the single-nucleotide polymorphism rs8099917, which is associated with IL-28B gene expression, to study its relationship to the susceptibility to schizophrenia. A total of 256 Chinese patients with schizophrenia and 329 healthy controls were studied. Both genotype and allele frequencies showed significant differences between patients and normal subjects (p=0.03 and p=0.04, respectively). Our study suggested that the frequency of allele T was a risk factor for the susceptibility of schizophrenia (odds ratio [OR]=1.76, 95% confidence interval [CI]=1.03-3.03). When all subjects were grouped by symptoms, both the genotype and the allele frequency were associated with patients having disorganized speech (genotype: χ(2)=5.75, p=0.02; allele: χ(2)=5.41, p=0.02, OR=3.67, 95% CI=1.14-11.82) and negative symptoms (genotype: χ(2)=5.09, p=0.02; allele: χ(2)=4.80, p=0.03, OR=1.95, 95% CI=1.06-3.56) as well as cognitive symptoms (genotype: χ(2)=5.97, p=0.02; allele: χ(2)=5.53, p=0.02, OR=2.04, 95% CI=1.11-3.74). The results in this study may lead to a better understanding of the etiology of schizophrenia.
精神分裂症是一种严重的精神疾病。虽然其确切病因尚不清楚，但普遍认为环境因素和基因在精神分裂症的发病机制中相互作用。19q13 包含 IL-28B，是一个新发现的潜在易感性位点。IL-28B 是一种细胞因子，具有抗病毒功能，但在结构上与白细胞介素-10 家族有关。病毒感染和细胞因子变化在精神分裂症中都有记录。我们选择与 IL-28B 基因表达相关的单核苷酸多态性 rs8099917 来研究其与精神分裂症易感性的关系。共研究了 256 例中国精神分裂症患者和 329 例健康对照者。患者与正常对照组的基因型和等位基因频率均有显著差异（p=0.03 和 p=0.04）。我们的研究表明，等位基因 T 的频率是精神分裂症易感性的危险因素（比值比[OR]=1.76，95%置信区间[CI]=1.03-3.03）。当根据症状将所有受试者分组时，基因型和等位基因频率均与言语紊乱的患者有关（基因型：χ(2)=5.75，p=0.02；等位基因：χ(2)=5.41，p=0.02，OR=3.67，95%CI=1.14-11.82）和阴性症状（基因型：χ(2)=5.09，p=0.02；等位基因：χ(2)=4.80，p=0.03，OR=1.95，95%CI=1.06-3.56）以及认知症状（基因型：χ(2)=5.97，p=0.02；等位基因：χ(2)=5.53，p=0.02，OR=2.04，95%CI=1.11-3.74）。本研究的结果可能有助于更好地理解精神分裂症的病因。
