From the Department of Medicine, Vanderbilt University School of Medicine.
and the Saint Thomas Medical Group, Saint Thomas Hospital, Nashville, TN.
J Clin Hypertens (Greenwich). 2012 Feb;14(2):121-132. doi: 10.1111/j.1751-7176.2011.00576.x. Epub 2012 Jan 17.
The combination of a lipid-lowering diet and scientifically proven nutraceutical supplements has the ability to significantly reduce low-density lipoprotein (LDL) cholesterol, increase LDL particle size, decrease LDL particle number, lower trigylcerides and very LDL levels, and increase total and high-density lipoprotein 2b cholesterol. In addition, inflammation, oxidative stress, and immune responses are decreased. In several prospective clinical trials, coronary heart disease and cardiovascular disease have been reduced with many nutraceutical supplements. This nutritional and nutraceutical supplement treatment is a valid alternative for patients who are intolerant to statins, cannot take other drugs for the treatment of dyslipidemia, or prefer alternative treatments. This new approach to lipid management to decrease vascular disease utilizes a functional medicine approach with a broader treatment program that will address the multitude of steps involved in lipid-induced vascular damage.
降脂饮食与经过科学验证的营养保健品相结合，具有显著降低低密度脂蛋白（LDL）胆固醇、增加 LDL 颗粒大小、减少 LDL 颗粒数量、降低甘油三酯和极低密度脂蛋白水平、增加总胆固醇和高密度脂蛋白 2b 胆固醇的能力。此外，还能降低炎症、氧化应激和免疫反应。在几项前瞻性临床试验中，许多营养保健品都能降低冠心病和心血管疾病的风险。对于不能耐受他汀类药物、不能服用其他治疗血脂异常的药物或更倾向于替代治疗的患者来说，这种营养和营养保健品的治疗方法是一种有效的选择。这种新的降脂方法旨在利用功能医学方法，制定更广泛的治疗方案，以解决脂质引起的血管损伤所涉及的多个步骤，从而降低血管疾病的风险。
