营养保健品在治疗血脂异常中的作用。
The role of nutraceutical supplements in the treatment of dyslipidemia.
机构信息
From the Department of Medicine, Vanderbilt University School of Medicine.
and the Saint Thomas Medical Group, Saint Thomas Hospital, Nashville, TN.
出版信息
J Clin Hypertens (Greenwich). 2012 Feb;14(2):121-132. doi: 10.1111/j.1751-7176.2011.00576.x. Epub 2012 Jan 17.
Abstract
The combination of a lipid-lowering diet and scientifically proven nutraceutical supplements has the ability to significantly reduce low-density lipoprotein (LDL) cholesterol, increase LDL particle size, decrease LDL particle number, lower trigylcerides and very LDL levels, and increase total and high-density lipoprotein 2b cholesterol. In addition, inflammation, oxidative stress, and immune responses are decreased. In several prospective clinical trials, coronary heart disease and cardiovascular disease have been reduced with many nutraceutical supplements. This nutritional and nutraceutical supplement treatment is a valid alternative for patients who are intolerant to statins, cannot take other drugs for the treatment of dyslipidemia, or prefer alternative treatments. This new approach to lipid management to decrease vascular disease utilizes a functional medicine approach with a broader treatment program that will address the multitude of steps involved in lipid-induced vascular damage.
摘要
降脂饮食与经过科学验证的营养保健品相结合，具有显著降低低密度脂蛋白（LDL）胆固醇、增加 LDL 颗粒大小、减少 LDL 颗粒数量、降低甘油三酯和极低密度脂蛋白水平、增加总胆固醇和高密度脂蛋白 2b 胆固醇的能力。此外，还能降低炎症、氧化应激和免疫反应。在几项前瞻性临床试验中，许多营养保健品都能降低冠心病和心血管疾病的风险。对于不能耐受他汀类药物、不能服用其他治疗血脂异常的药物或更倾向于替代治疗的患者来说，这种营养和营养保健品的治疗方法是一种有效的选择。这种新的降脂方法旨在利用功能医学方法，制定更广泛的治疗方案，以解决脂质引起的血管损伤所涉及的多个步骤，从而降低血管疾病的风险。
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本文引用的文献
1
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Curr Opin Lipidol. 2011 Oct;22(5):386-93. doi: 10.1097/MOL.0b013e32834adadb.
2
Tocotrienols and cardiovascular health.生育三烯酚与心血管健康。
Curr Pharm Des. 2011;17(21):2147-54. doi: 10.2174/138161211796957418.
3
Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial.超重和肥胖男性中绿茶儿茶素的健康影响：一项随机对照交叉试验。
Br J Nutr. 2011 Dec;106(12):1880-9. doi: 10.1017/S0007114511002376. Epub 2011 Jun 7.
4
Beyond cholesterol-lowering effects of plant sterols: clinical and experimental evidence of anti-inflammatory properties.植物固醇除了能降低胆固醇外：具有抗炎特性的临床和实验证据。
Nutr Rev. 2011 Jul;69(7):371-82. doi: 10.1111/j.1753-4887.2011.00399.x. Epub 2011 Jun 30.
5
Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials.绿茶摄入可降低成年人空腹血清总胆固醇和 LDL 胆固醇：14 项随机对照试验的荟萃分析。
Am J Clin Nutr. 2011 Aug;94(2):601-10. doi: 10.3945/ajcn.110.010926. Epub 2011 Jun 29.
6
Metabolic and functional relevance of HDL subspecies.高密度脂蛋白亚类的代谢和功能相关性。
Curr Opin Lipidol. 2011 Jun;22(3):176-85. doi: 10.1097/MOL.0b013e3283468061.
7
Myeloperoxidase is associated with incident coronary heart disease independently of traditional risk factors: results from the MONICA/KORA Augsburg study.髓过氧化物酶与传统危险因素独立相关：来自 MONICA/KORA 奥格斯堡研究的结果。
J Intern Med. 2012 Jan;271(1):43-50. doi: 10.1111/j.1365-2796.2011.02397.x. Epub 2011 May 30.
8
Low coenzyme Q₁₀ levels and the outcome of statin treatment in heart failure.心力衰竭中辅酶Q₁₀水平低与他汀类药物治疗的结果
J Am Coll Cardiol. 2011 Apr 5;57(14):1569; author reply 1569. doi: 10.1016/j.jacc.2010.10.051.
9
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Clin Cardiol. 2011 Mar;34(3):172-7. doi: 10.1002/clc.20847. Epub 2011 Feb 1.
10
Clinical implications of discordance between low-density lipoprotein cholesterol and particle number.载脂蛋白 B 与载脂蛋白 B 颗粒数对 LDL 胆固醇水平的影响。
J Clin Lipidol. 2011 Mar-Apr;5(2):105-13. doi: 10.1016/j.jacl.2011.02.001.
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