Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
Nutr Metab (Lond). 2012 Jan 25;9(1):4. doi: 10.1186/1743-7075-9-4.
The prevalence of gastroesophageal reflux disease (GERD) has been increasing worldwide. Abdominal obesity or visceral fat accumulation rather than simple obesity is associated with GERD. Previous reports demonstrated the association between GERD and type 2 diabetes mellitus (T2DM). Signification of visceral fat accumulation and adiponectin in T2DM patients with GERD remains unclear. The present study investigated the relationships between GERD symptoms, visceral fat accumulation and adiponectin in subjects with T2DM.
The study (ADMIT study) subjects were 66 Japanese T2DM outpatients, who answered the questionnaire regarding GERD symptoms in Frequency Scale for the Symptoms of GERD (FSSG), and were measured visceral fat area by bioelectrical impedance analysis. Patients with FSSG scores of more than 8 were considered as positive. The prevalence of FSSG score ≥ 8 and average FSSG score in T2DM subjects with the metabolic syndrome (Mets) were significantly higher compared to those without Mets. The prevalence of FSSG score ≥ 8 and average FSSG score in T2DM subjects with low levels of serum adiponectin were significantly higher compared to those with high levels of serum adiponectin. Moreover, the combination of Mets and hypoadiponectinemia had a multiplicative effect on GERD symptom score (p = 0.047).
Our study showed that the coexistence of MetS and low levels of serum adiponectin was associated with the higher prevalence of FSSG score ≥ 8 and the higher scores of GERD symptom in subjects with T2DM.
UMIN 000002271.
胃食管反流病（GERD）的患病率在全球范围内呈上升趋势。腹部肥胖或内脏脂肪堆积而非单纯性肥胖与 GERD 相关。先前的报告表明 GERD 与 2 型糖尿病（T2DM）之间存在关联。GERD 合并 T2DM 患者内脏脂肪堆积和脂联素的意义尚不清楚。本研究旨在探讨 GERD 症状、内脏脂肪堆积与 T2DM 患者脂联素之间的关系。
本研究（ADMIT 研究）的对象是 66 名日本 T2DM 门诊患者，他们回答了关于 GERD 症状的频率量表（FSSG）问卷，并通过生物电阻抗分析测量了内脏脂肪面积。FSSG 评分>8 分的患者被认为是阳性。T2DM 合并代谢综合征（Mets）患者的 FSSG 评分≥8 的患病率和平均 FSSG 评分明显高于不合并 Mets 的患者。血清脂联素水平较低的 T2DM 患者的 FSSG 评分≥8 的患病率和平均 FSSG 评分明显高于血清脂联素水平较高的患者。此外，Mets 和低血清脂联素血症的共存对 GERD 症状评分有相乘作用（p=0.047）。
本研究表明，Mets 和低血清脂联素血症的共存与 T2DM 患者 FSSG 评分≥8 的患病率较高和 GERD 症状评分较高相关。
UMIN 000002271。
