Sun Huihui, Yi Lisha, Wu Ping, Li Yingjie, Luo Bin, Xu Shuchang
Department of Gastroenterology, Tongji Institute of Digestive Diseases, Tongji Hospital, Tongji University, No. 389 Xin Cun Road, Shanghai 200065, China.
Department of Clinical Nutrition, Tongji Hospital, Tongji University, No. 389 Xin Cun Road, Shanghai 200065, China.
Gastroenterol Res Pract. 2014;2014:601571. doi: 10.1155/2014/601571. Epub 2014 Oct 29.
Background/Aims. Patients with type II diabetes mellitus (DM) were known to have higher prevalence of gastroesophageal reflux disease (GERD) in the Western countries, but data on the impact of GERD on DM patients in our country are scarce. The aim of this study was to evaluate the prevalence of GERD in type II DM patients in Shanghai, China, and to explore its possible risk factors. Methods. 775 type II DM cases were randomly collected. Reflux Disease Questionnaire (RDQ) was used to check the presence of GERD. Patients' characteristics, laboratory data, face-to-face interview, nerve conduction study, and needle electromyogram (EMG) test were analyzed. Results. 16% patients were found with typical GERD symptoms. Pathophysiological factors such as peripheral neuropathy, metabolism syndrome, and obesity were found to have no significant differences between GERD and non-GERD type II DM patients in the present study. Conclusion. The prevalence of GERD in type II DM patients is higher than that in adult inhabitants in Shanghai, China. No difference in pathophysiological factors, such as peripheral neuropathy, and metabolism syndrome was found in DM-GERD patients, suggesting that further study and efforts are needed to explore deeper the potential risk factors for the high prevalence rate of GERD in DM patients.
背景/目的。在西方国家，已知2型糖尿病（DM）患者胃食管反流病（GERD）的患病率较高，但我国关于GERD对糖尿病患者影响的数据较少。本研究的目的是评估中国上海2型糖尿病患者中GERD的患病率，并探讨其可能的危险因素。方法。随机收集775例2型糖尿病病例。采用反流病问卷（RDQ）检查GERD的存在情况。分析患者的特征、实验室数据、面对面访谈、神经传导研究和针极肌电图（EMG）检查结果。结果。发现16%的患者有典型的GERD症状。在本研究中，发现周围神经病变、代谢综合征和肥胖等病理生理因素在GERD和非GERD的2型糖尿病患者之间无显著差异。结论。2型糖尿病患者中GERD的患病率高于中国上海成年居民。在糖尿病合并GERD患者中，未发现周围神经病变和代谢综合征等病理生理因素存在差异，这表明需要进一步研究和努力，以更深入地探索糖尿病患者中GERD高患病率的潜在危险因素。
