Passive immunotherapy of sepsis with intravenous immune globulin: not all IVIg preparations are created equal.
作者信息
Vassilev Tchavdar, Bauer Michael
出版信息
Crit Care. 2012 Jan 25;16(1):407. doi: 10.1186/cc10607.
Abstract
摘要
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Passive immunotherapy of sepsis with intravenous immune globulin: not all IVIg preparations are created equal.静脉注射免疫球蛋白用于脓毒症的被动免疫疗法：并非所有静脉注射免疫球蛋白制剂都是一样的。
Crit Care. 2012 Jan 25;16(1):407. doi: 10.1186/cc10607.
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本文引用的文献
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Treatment of neonatal sepsis with intravenous immune globulin.静脉注射免疫球蛋白治疗新生儿败血症。
N Engl J Med. 2011 Sep 29;365(13):1201-11. doi: 10.1056/NEJMoa1100441.
2
Exposure of IgG to an acidic environment results in molecular modifications and in enhanced protective activity in sepsis.IgG 在酸性环境下暴露会导致分子修饰，并增强其在脓毒症中的保护活性。
FEBS J. 2010 Jul;277(14):3039-50. doi: 10.1111/j.1742-4658.2010.07714.x. Epub 2010 Jun 8.
3
Protein destabilizing agents induce polyreactivity and enhanced immunomodulatory activity in IVIg preparations.
Autoimmunity. 2009 May;42(4):365-7. doi: 10.1080/08916930902832181.
4
Ferrous ions and reactive oxygen species increase antigen-binding and anti-inflammatory activities of immunoglobulin G.亚铁离子和活性氧可增强免疫球蛋白G的抗原结合及抗炎活性。
J Biol Chem. 2006 Jan 6;281(1):439-46. doi: 10.1074/jbc.M509190200. Epub 2005 Oct 24.
5
The autoreactivity of therapeutic intravenous immunoglobulin (IVIG) preparations depends on the fractionation methods used.治疗性静脉注射免疫球蛋白（IVIG）制剂的自身反应性取决于所使用的分级分离方法。
Scand J Immunol. 2005 Apr;61(4):357-63. doi: 10.1111/j.1365-3083.2005.01568.x.
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